ABSTRACT
The South eastern region of Iran is an endemic area for salmonellosis. Sometimes bacteremia due to nontyphoidal salmonella occurs but certain patients are at increased risk for recurrent bacteremia. The risk of invasive salmonellosis and recurrent bacteremia is increased in the patients with immunosuppression, especially impaired cell-mediated immunity, lymphoproliferative diseases and in patients with IL-12 deficiency. In recent years, a series of inherited disorders of IL-12-IFN-gamma axis have been described that predispose affected individuals to disseminated disease caused by environmental mycobacteria and non-typhoidal salmonella. We report here the first such patient originating from and living in Iran. The patient was a 26-year-old man, suffering from IL-12p40 deficiency and presented with recurrent episodes of systemic salmonellosis. This report indicates that there are patients with inherited defects of the IL-12-IFN-gamma circuit in Iran. We recommended to consider this group of disorders in all patients with recurrent non-typhoidal salmonella bacteremia, wherever they are found
ABSTRACT
Introduction: hepatitis B virus is one of the most common chronic infections in the world. Over half of the world population has been exposed to this virus. It is estimated that 3% of Iranian population are - chronic carriers
Objective: to determine the seroprevalence of hepatitis B infection in pregnant women in Zahedan, Iran
Method: in this cross-sectional study in a period of one month in Zahedan, total cases of 200 pregnant women were enrolled in our study. Sera obtained from these pregnant women were evaluated for HBsAg by ELISA method
Result: our data showed that 6.5% of the pregnant women had a positive test for HBsAg
Conclusion: it seems that hepatitis B infection is highly endemic at least in pregnant women in Zahedan. On the basis of these epidemiologic data, screening of all pregnant women is necessary