ABSTRACT
Background: genetic factors are candidates for about 30% of male infertility with sperm production-related abnormalities. Y chromosome microdeletions are responsible for around 10% of male infertility. These microdeletions generally occur in azoospermia factor on the Yq. That is often associated with the quantitative reduction of sperm
Objective: the aim of this cross-sectional study was to determine the frequency of Yq microdeletions among idiopathic azoospermic, oligoasthenozoospermic, and oligospermic men in Shohada infertility center, Chaharmahal va Bakhtiari province
Materials and Methods: a total of 81 idiopathic azoospermic, oligoasthenozoospermic, and oligospermic infertile men were selected as cases and 81 fertile men assigned to control group. For molecular investigations, 13 sequance tagged sitemarkers were chosen from azoospermia factor [AZF] region for detection of Y chromosome microdeletions and amplified by two separate multiplex-polymerase chain reaction. The relationship between the AZF microdeletions and incidence of male infertility in the family, consanguineous parents, smoking, and the levels of reproductive hormones among infertile men were investigated.The relationship between the AZF microdeletions and incidence of male infertility in the family, consanguineous parents, smoking, and the levels of reproductive hormones among infertile men were investigated
Results: the total frequency of the microdeletions was 6.17% [2 cases in azoospermic, 3 cases in oligoasthenozoospermic subgroups, and none in the oligospermic participants and the control group]. Most deletions [3.7%] were seen in the AZFb followed by the AZFc [2.46%] and none in AZFa. No significant association was seen between the microdeletions and clinical characteristics
Conclusion: although the frequency of Yq chromosome microdeletions in Chaharmahal va Bakhtiari province is lower than the mean frequency of Iran, the frequency is comparable to those reported by some studies in Iran
ABSTRACT
Horseshoe placenta is a variant of ring-shaped placenta. Ring-shaped placenta is a rare anomaly seen in fewer than 1 in 6000 deliveries, which could be seen as horseshoe shape due to atrophy in a portion of the ring. This report refers to a possible relationship between the horseshoe shape placenta and preterm labor; although it has not been yet validated in the literature. In this case report we present the placenta of a 35 years-old G2L1 woman who was referred to delivery unit of Shohada Hospital in Ghouch, Iran with starting of labor pain at 34 weeks of gestation who gave birth to a live-born female baby with 6/8 APGAR score. The amniotic fluid was meconium-stained. The patient had no evidence of fever, bleeding, infection. It is concluded that due to the risks to the fetus and mother caused by horseshoe placenta, its timely diagnosis during pregnancy using ultrasound is important and leads to early detection and better management of pregnancies complicated with placental abnormalities