ABSTRACT
Statement of the Problem: Oral lichen planus [OLP] is a chronic inflammatory disorder with various clinical features; however, its pathogenesis is still unknown. In OLP, destruction of the basement membrane and migration of T-cell may be mediated by matrix metalloproteinases
Purpose: The aim of this study was to examine the role of stromelysin-2 [ST-2] expression in pathogenesis of OLP
Materials and Method: A retrospective analysis of 46 samples including 26 patients with OLP and 20 control patients with oral irritation fibroma was performed. All samples were stained employing immunohistochemistry method. After immunohistochemical staining for ST-2 marker and microscopic examination of the samples, the expression levels of ST-2 were evaluated. The data were analyzed by SPSS [V.21] and applying Mann-Whitney test
Results: The strength of ST-2 expression was seen in most cases of OLP group, whereas control group did not show ST-2 expression. Mean expression of ST-2 in connective tissue was 1.7 +/- 1.10 and in the epithelium of the OLP samples was 1.6 +/- 1.06. Likewise, the ST-2 expression in connective tissue and epithelium of the OLP erosive lesions was significantly higher in comparison with reticular lesions [p< 0.05]
Conclusion: According to the results of this study, we suggest that ST-2 may be involved in the formation of OLP lesions and it may play a key role in the transformation of reticular to erosive form of OLP
ABSTRACT
The aim of this study was to determine the prevalence and viral load of Epstein-Barr virus [EBV] and Human herpesvirus-6 [HHV-6] in different histopathologic grades of oral squamous cell carcinoma [OSCC]. Forty-five formalin-fixed paraffin-embedded tissue section of OSCC patients were analyzed by quantitative real-time polymerase chain reaction for detection of EBV and HHV-6. The mean age of the patients was 58.6 years, 69% of whom were female, and 31% were male. Overall, the positive rate for EBV and HHV-6 were 16.7% and 27.1%, respectively; and the mean viral load EBV was 27.9 x 10[3] and 38.5 x 10[3] for HHV-6. No correlation was demonstrated between the viral load of EBV DNA [P = 0.35] and HHV-6 [P = 0.38] at the different OSCC histopathologic grades. These findings neither lend support to the hypothesis that EBV and HHV-6 are directly involved in OSCC nor rule out the possibility that these viruses play an indirect role in carcinogenesis in this area
Subject(s)
Humans , Male , Female , Carcinoma, Squamous Cell , Herpesvirus 6, Human , Roseolovirus Infections , Herpesvirus 4, Human , Epstein-Barr Virus InfectionsABSTRACT
Neurofibroma is a benign neoplasm derived from peripheral nerve cells. Neurofibroma can occur as a solitary tumor also it may associate with neurofibromatosis. Intraosseous neurofibroma is a rare tumor particularly in the oral cavity. So far, few cases of solitary intraosseous neurofibroma of the mandible have been reported. In the present study, a 39 years old woman which has a diagnosis of solitary intraosseous neurofibroma of the mandible is reported. Clinical, radiographic, histopathologic and immunohistochemical features are described
ABSTRACT
Pyostomatitis vegetans [PV] is a rare chronic inflammatory disease of unknown etiology. Oral appearance are the first symptoms. One of the less common clinical features is erosions which tend of form granulation tissue, and finally develop a vegetative looking, especially in the skin folds and heal and face. In clinical examination diffuse vegetation and snail tract was found
Subject(s)
Humans , Female , Lip/pathology , Cheek/pathologyABSTRACT
Odontogenic tumors constitute an important aspect of oral and maxillofacial pathology. Frequency of odontogenic tumors varies in different societies but no study has been done in Zahedan so far. The purpose of this study was to achieve the sex, location and age distribution of odontogenic tumors and frequency of each one in a period of ten years. In this study, documents in archive of maxillofacial pathology department of Zahedan dental school, Khatamolanbia, Tamin ejtemaei Hospital and private laboratories were reviewed from 2000 to 2010. Data about age, sex, location of tumors and relation with impacted tooth were extracted and were submitted in the forms. In this study, among the 1125 cases of the oromaxillofacial lesions, 50 cases of odontogenic tumors were found. Among the different tumors, keratocyst odontogenic tumor [KOT] was the most common odontogenic tumor [48%], followed by ameloblastoma and odontoma with frequency of 24% and 12%, respectively. There were no cases of malignancy. The incidence of these lesions was 52% in women and 48% in men. The most common location of tumors was posterior of mandible and tumors were more frequent in the third decade of life. In 12 cases, the lesions were accompanied by impacted teeth. In this study the most frequent tumors were KOT, Ameloblastoma and odontoma respectively.
ABSTRACT
Currently, diabetes is a basic problem in many countries. Increase in the prevalence of diabetes places dentists in the position of the first member of a health care team to detect new cases of diabetes. Besides, dentists must also be able to render dental care to patients who are already being treated for diabetes. Because of importance of glycemic control of diabetic patients in dental treatment plan and strong correlation between oral complications and level of glycemic control, the purpose of this study was to evaluate the level of glycemic control in diabetic dental patients before dental procedures. At this cross sectional study, 100 diabetic patient's reffered to Oral Medicine Department of Zahedan Dental School, were studied [from May to March 2005]. After an informed consent of diabetic patients, patient's blood sample was taken in standard conditions, sent to laboratory to detect level of HbA1c and the level of glycemic control was determined in patients. Data were analyzed by the Chi-square, Mann-Whitney, Kruskal-Wallis and t-tests. Thirty two percent of patients had good glycemic control [6%