ABSTRACT
Background: Non-alcoholic fatty liver disease [NAFLD] is the most common chronic liver disease that exposes patients to a great risk of emerging cardiovascular diseases and could develop to cirrhosis or hepatocellular carcinoma if left unmanaged
Objective of the Study: this article is intended to provide an overview and explore the optimal intervention for management of NAFLD in the short and long term
Methods: Electronic search in the scientific database from 1966 to 2017 [Medline, Embase, the Cochrane Library as well as NHS center websites were searched for English Publications were obtained from both reprint requests and by searching the database. Data extracted included authors, country, year of publication, age and sex of patients, epidemiology, geographical distribution, pathophysiology, risk factors, clinical manifestations, investigations and types of surgical treatment
Conclusion: It was concluded from the extensive review of the literature that Lifestyle modification including diet, physical activity and controlling metabolic disorders are the cornerstone in current management of NAFLD. Nevertheless, Insulin-sensitizing agents and antioxidants, particularly thiazolidinediones and vitamin E, seem to be a very promising pharmacologic treatment for non-alcoholic steatohepatitis, yet further long-term multicenter studies need to be conducted for confirmation and assessment
ABSTRACT
Objective: The aim of the study is to assess the effect of tobacco smoking on the risk of nonfatal acute myocardial infarction in young adults less than years
Materials and methods: We conducted a population-based case-control study with 164 occurrence acute myocardial infarction cases [21 women; 143 men], consecutively visited King Abdulaziz hospital, KSA, and 227 controls [81 women; 146 men], From February 2016 till February 2017. All women are non-Saudi women. Odds ratios [OR] and 95% confidence intervals [95%CI] were calculated using unconditional logistic regression
Results: The commonness of present smoking was 81% in male cases and 54% in male controls [OR = 3.59, 95%CI: 2.49, 5.31] and 60% of female cases were smokers compared with 36% of controls [OR = 2.65, 95%CI: 1.40, 4.98]. No interaction was found between current smoking and gender on myocardial infarction risk [P = 0.399]. A dose-effect response was present, the odds favoring myocardial infarction reaching an eight-fold increase for those who smoked >25 cigarettes/day compared with never smokers. The risk estimate for former smokers was similar to never smokers
Conclusions: Tobacco smoking is an important independent risk factor for acute myocardial infarction in young adults, with similar strength of association for both genders