Clinical Study of Shigellosis

Clinical and Bacteriological studies were carried out on 57 cases of infants and children with shigellosis who were cared from January, 1976 to December, 1980 in our hospital. The results were as follows: 1. The age distribution revealed the range between 6 months and 5 years(85% of all) with sex ratio of 30(53%) of male and 27(47%) of female, 1.1:1. 2. The peak incidence was noted in summer, althought there were occurrence throughout the year, even in winter. 3. On bacteriological studies, Shigellan flexneri was isolated most frequenty(90%) and Shigella sonnei was the next(8.8%). 4. Only 8.3% of Shigella strains were resistant to ampicillin between 1976 and 1977 but resistance increased to 76.7% in 1980. Gentamicin and Kanamycin which are aminoglycosiides were quite effectived but their use was limited becauseof their nephrotoxicity. 5. The average duration from the onset to the clinical improvement including stool character in the 32 ampicillin treated patients was 3.6 days and in the 25 rifampin treated patients was 2.2 days. Rifampin was effective in eradicating the shigella stralins and stool cultures taken at 7th therapeutic day remained negative in all 25 rifampin treated patients but yielded growth of shigella strains in 13 ampicillin treated patients. There was no doubt that rfaimpin was superior to ampicillin for bacillary dysentry. 6. One of these 57 cases was expired and motality rate was 1.8%.

A Case of the Pancreatic Pseudocyst

No abstract available.

Two Cases of Moyamoya Disease

Moyamoya disease is characterised by stenosis or occlusion in the distal portions of the internal carotid artery. There is the associated finding of a fine network of abnormal vessels ('moyamoya' vessels, that is 'puff of smoke' like appearance) in the region of the basal ganglia. We experienced two cases of moyamoya disease which was confirmed by carotid angiogram. Case 1 had complaints of speech disturbance and clonic movement of right leg. Case 2 had been suffered from transitory repetitive paroxysmal hemiplegia. Review of literatures and references on moyamoya disease was done briefly.

Two Cases of Cri Du Chat(5p-) Syndrome

We have experienced two cases of the Cri Du Chat Syndrome. The first case, 1 and 11/12 year old female, was admitted to evaluated profound mental retardation and failure to thrive. The other, 3 month old female, visit this dept for cat-like cry. They had the typical clinical characteristics of the Cri Du Chat Syndrome and showed showed the classical chromosome abnormality (46, XX 5p-), revealed by cytogenetic study.

Clinical Studies of Typhoid Fever in Childhood

During the last 7 years from Jan. 1973 to Dec. 1979, 106 cases of typhoid fever has been admitted to the department of Pediatrics of Won Ju Christian Hospital and evaluated clinicaIly. The results were summarized as follows 1. Tota1 number of the patients was 106, of which 62 were male and 44 were female. The peak age group was over 11 years of age and the youngest case was 6 month old male patient. The seasonal incidence was high in July to September. 2. The clinical symptoms on admission were as follows: fever(93.4%), abdominal pain(56.6%), headache(26.4%), nausea and vomiting(25.5%), diarrhea(20.3%) and cough(16.0%) The physical findings were as follows: fever(68.9~), injected throat(56. 690), hepatomegaly(50.0%), coated tongue(45.3%), abdominal tenderness(33.0%), splenomegaly(20.8%) and bradyeardie(16.0%). 3. Anemia was 41.590 and leukopenia was 27.4%. Widal test was positive in 73.6% of all 129 tests. The positive bacteriologic cultures were 56.9% in blood and 10.4% in stool, respectively. 4. The average days of defevervescence was 3. 66 days in CM, 3. 88 days in ampicillin, 2.80days in CM combined with ampicillin and 2.71 days in ampicillin with prednisolone, of each. The doplication was noted in 24 cases(22.6%), which included pneumonia(7 cases), intestinal perforation(7 cases) and intestinal hemorrhage(3 cases).