1.
Chinese Journal of Biochemistry and Molecular Biology
;
(12): 1281-1289, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-1015853
ABSTRACT
Sirtuins belongs to the class III family of histone deacetylases (HDAC), which is a mammalian homolog of the yeast silencing information regulator Sir2. Silent information regulator factor 2-related enzyme 1 (SIRT1) is the most well studied family member of Sirtuins. Distributed mainly in the nucleus and cytoplasm, SIRT1 is involved in various intracellular biological processes, including DNA damage repair, gene transcription, energy metabolism, stress and apoptosis through its NAD