ABSTRACT
Objective To investigate the influence of sevoflurane and propofol on postoperative cognitive dysfunction in elderly patients with laparoscopic cholecystectomy.Methods Sixty elderly patients scheduled for elective laparoscopic cholecystectomy in our hospital from March 2016 to September 2016 were selected and divided into the sevoflurane group(S) and propofol group (P),30 cases in each group.Postoperative mini-mental state examination(MMSE) score and occurrence rate of postoperative cognitive dysfunction(POCD) were compared between two groups.Results The MMSE score at T0 had no statistical difference between the two groups;the MMSE score at T1 and T2 in the group S was significantly lower than that in the group P,moreover the occurrence rate of POCD at T1 in the group S was significantly higher than that in the group P;The MMSE score and POCD occurrence rate at T3 had no statistical difference between the two groups(P＞0.05).The MMSE score at T1,T2 and T3 in the group S was significantly decreased compared with that at T0 (P＜0.05);the MMSE score at T1 and T2 in the group P was significantly decreased compared with that at T0 (P＜ 0.05),and which at T3 was gradually recovered.Conclusion Compared with propofol,sevoflurane has more significant and persistent influence on POCD occurrence.
ABSTRACT
Objective To investigate the influence of sevoflurane and propofol on postoperative cognitive dysfunction in elderly patients with laparoscopic cholecystectomy.Methods Sixty elderly patients scheduled for elective laparoscopic cholecystectomy in our hospital from March 2016 to September 2016 were selected and divided into the sevoflurane group(S) and propofol group (P),30 cases in each group.Postoperative mini-mental state examination(MMSE) score and occurrence rate of postoperative cognitive dysfunction(POCD) were compared between two groups.Results The MMSE score at T0 had no statistical difference between the two groups;the MMSE score at T1 and T2 in the group S was significantly lower than that in the group P,moreover the occurrence rate of POCD at T1 in the group S was significantly higher than that in the group P;The MMSE score and POCD occurrence rate at T3 had no statistical difference between the two groups(P＞0.05).The MMSE score at T1,T2 and T3 in the group S was significantly decreased compared with that at T0 (P＜0.05);the MMSE score at T1 and T2 in the group P was significantly decreased compared with that at T0 (P＜ 0.05),and which at T3 was gradually recovered.Conclusion Compared with propofol,sevoflurane has more significant and persistent influence on POCD occurrence.