To investigate the relationship of airborne fungi and allergic disease of respiration system in the city of Wuhan region / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the relationship between the prevalent species and the seasonal drift law of airborne fungi and respiratory allergic disease in the city of Wuhan.@*METHOD@#Airborne fungi was investigated by exposed sides from 2007 to 2008, and 1674 patients with respiratory allergic disease that were used to do allergens skin test simultaneously, in order to analyze the simultaneous.@*RESULT@#Airborne fungi could be detected in air all over the year. In 2007, the exposed films collected 26 734 fungi spores, and 686 other fungi (hypha and not well known fungi), to the sum of 27420. Otherwise, in 2008, the exposed films collected 26 531 fungi spores, and 730 other fungi, to the sum of 27 261. In the survey, 17 types of species of the collected fungi spores were identified, and the predominant species were alternaria sp, ustilaginales, deightoniella sp, uredinales, and the quantity of Fungi alternaria was most of all . And the peak period mainly concentrated from April to June, and from September to October. Otherwise, the positive rate of fungi skin test in patients with respiratory allergic disease was 10.48% in 2007, but 10.07% in 2008. The main period of onset of respiratory allergic disease was from April to June, and from September to October, similar as the seasonal drift law of airborne fungi.@*CONCLUSION@#The period of onset of respiratory allergic disease was consistent with the seasonal drift law of airborne fungi.

The effect of specific immunotherapy on the regulation of Th1/Th2 cell ratio of the patients with allergic rhinitis in serum / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To explore the effects of specific immunotherapy by the nasal spray and/or sublingual contain on the regulation the balance of serum Th1/Th2 cell ratio, and the expression of total IgE (tIgE) level in perennial allergic rhinitis patients.@*METHOD@#Thirty-six cases of allergic rhinitis of perennial (PAR) patients with nasal specific immunotherapy (nasal spray group) were chosen as the object of study, 36 PAR patients with sublingual specific immunotherapy (sublingual group) were chosen for the efficacy comparison group, and 32 cases of healthy adults as control (normal control group). The levels of serum IL-2, IL-4, IL-8 and tIgE in PAR nasal spray group and sublingual group were examined by IRMA and double-antibody sandwich assay before and after the treatment of specific immunotherapy (SIT); The content of IFN-gamma was determined by enzyme-linked immunosorbent assay; The infiltration and changes of eosinophilic granulocyte were observed by the smear of nasal secretions.@*RESULT@#In nasal spray group and sublingual group, the contents of serum Th1 cytokines IL-2 and IFN-gamma were reduced levels significantly, while the contents of Th2 cytokines IL-4, IL-8 and tIgE were significantly increased before the treatment of SIT. After the SIT to the maintenance dose, the levels of IL-2 and IFN-gamma in serum were significantly higher than that before treatment, while IL-4, IL-8 and tIgE content were significantly lower in AR patients (P 0.05).@*CONCLUSION@#With the presence of Th1/Th2 cell ratio and cytokine imbalance, the AR patients manifested as Th2 cell function in accentuation. Nasal mucosa and/or sublingual in the local SIT can have changed no-balance Th1/Th2 cell of by regulating the balance of serum Th1/Th2 cell ratio, the expression level of cytokine expression and the level of tIgE.

Ways and Effects of deepening the reform of the operational system of our hospital / 中华医院管理杂志

In order to orient medical service towards the needs of patients, put quality at the core of medical practice and take doctors as the axis, we started the deepening of the reform of the operational system of our hospital at the juncture when patients were allowed to select their doctors. Ways adopted include: creation of a sound environment of competition through management focused on personnel; promotion of the healthy development of the move of letting patients select their doctors via management focused on personnel; stimulation of doctors through dynamic competition based on management focused on personnel. The following good effects have been achieved. ①In the period lasting from January to June 2001, as compared with the same period of the previous year, the outpatient volume increased by 30 042 visits, the number of discharged cases increased by 1 275, and the consumption of health materials per hundred yuan of medical income dropped by 5.28%. ②Solutions were found to problems which had existed for a long time in the management of the hospital but which had failed to be solved, problems like engagement of people with senior professional titles on lower posts, improper relationship between senior, middle-aged and young personnel, and misunderstandings regarding management. ③A dynamic operational system was formed inside the hospital.