ABSTRACT
Background: The prevalence of metabolic syndrome [MetS] in polycystic ovary syn-drome [PCOS] has been studied in different populations, but their results were so con-troversial regarding Iranian women. These controversial data indicated the need for more investigation of MetS characteristics in PCOS patients in our population. So this study aimed to evaluate the clinical and laboratory characteristics and metabolic features of patients with PCOS in Rasht
Materials and Methods: This prospective cross sectional study was conducted on 215 PCOS women who lived in Rasht, north of Iran, from March 2010 to July 2012. The participants were then divided into two groups of women with MetS [n=62] and women without MetS [n=153]. The diagnosis of PCOS and MetS were based on the Rotterdam 2003 criteria and the Adult Treatment Panel III [ATP III] criteria, respectively. Demographic characteristics, fertility characteristics, family history and laboratory findings were assessed
Results: The prevalence of MetS in women with PCOS was 28.8%. In PCOS women of both groups, the waist circumference [WC] exceeded 88cm in 72.6%, hypertension [systolic blood pressure [SBP] and/or diastolic blood pressure [DBP] >/= 130/85mm Hg] was prevalent in 9.3%, fasting blood sugar [FBS] level was >/= 110 mg/dl in 6%, triglycerides [Tg] level were >/= 150 mg/dl in 47%, and high-density lipoprotein [HDL] level was <50 mg/dl in 86%. The values of WC, SBP, DBP, body mass index [BMI], ovarian size, Tg, cholesterol, FBS, 2-hour blood sugar, aspartate aminotransferase [AST], and alanine aminotransferase [ALT] were significantly greater in PCOS women with MetS than women without MetS. Also HDL and luteinizing hormone [LH] levels in women with MetS were significantly lower than women without MetS
Conclusion: Prevalence of MetS in PCOS women was 28.8%, indicating that this value is higher than other studies conducted on PCOS women in Iran and other studies conducted on general population in Iran. PCOS women are considered as a high-risk population for MetS. The special strategies are required to prevent MetS and its associated complications in PCOS women
ABSTRACT
Background: Physical exercise is known to be a stressor stimulus that leads to reproductive disruption
Objective: The aim of this study was to evaluate the effect of forced swimming on the uterus and ovaries in mice
Materials and Methods: Adult mice [N=24] were divided into the following three groups: A, control; B, swimming in water [10°C]; and C, swimming in water [23°C]
Swimmers swam for 5 min daily for 5 consecutive days/ wk during 2 wks. An enzyme linked immunosorbent assay was used to determine serum estradiol, follicle stimulating hormone [FSH] and testosterone levels. Immunohistochemistry was performed to study apoptotic cells or estrogen receptor [ER] expression in uterine epithelial cells and ovaries. ANOVA was used for statistical analysis
Results: Swimming in both groups reduced the serum FSH and estradiol levels [p<0.01] without having a significant effect on the serum testosterone level or percentage of apoptosis in ovarian and uterine tissues [p<0.01] compared with controls. A significant reduction in the number of ERs in the uterus and ovaries, and secondary and graafian follicles were observed in groups B and C compared with controls [p<0.01]; however the number of primordial and primary follicles were not significantly changed in the ovaries
Conclusion: Forced swimming of 2 wks duration reduces the serum levels of FSH and estradiol without having effects on apoptosis in the ovaries or uteri of mice
Over a long period of time, forced swimming may have an adverse effect on fertility
ABSTRACT
Spontaneous coronary artery dissection is a rare cause of acute coronary syndrome and sudden cardiac death. We report coronary artery dissection in a 36-year-old woman with retrosternal chest pain 2 weeks after abortion. Electrocardiography showed ST elevation in leads V2-V4 and ST depression in the inferior leads. Lab data were normal. Cardiac catheterization showed a suspicious thrombotic lesion at the proximal portion of the left anterior descending artery with a smooth contour consistent with distal haziness and dissection site. Final diagnosis was coronary artery dissection. At 1 week's follow-up, the patient was in good physical condition. At 1 month's follow-up, she had no complaints of discomfort. And finally, 8 months after having suffered a heart attack, she presented no evidence of angina, dyspnea, or congestive heart failure Spontaneous coronary artery dissection is a rare disease that mainly affects younger women. Compared with earlier reports, the prognosis seems to be improved by early diagnosis and interventional treatment
ABSTRACT
A potential brain damage, as a result of premature birth, can cause damage to intelligence quotient [IQ]. Due to the high incidence of preterm birth and its associated disorders and its impact on society and according to a few studies in this field, this study with the aim of evaluating association between IQ and preterm birth was conducted. This historical cohort study was done on 282 children of school age, dividing into two groups of cohort [n = 147] and controls [n = 156]. Demographic characteristics and findings of Raven's test for assessing IQ were gathered in children. Data were analyzed by SPSS software at a significance level of less than 0.05. The mean and standard deviation of IQ in cohort groups and control were the 99.46 +/- 9.91 and 100.02 +/- 8.61, respectively. The mean gestational age was 33.74 weeks in cohort group and 38.63 weeks in the control group. Mean birth weight and head circumference in the cohort and control group were 2226.81gr, 32.72 cm and 3260.57gr, 33.97 cm, respectively. Mean score of IQ was not significantly different between two groups, but IQ had significant correlation with birth weight and head circumference [r=0.179, P=0.002 and r=0.299, P<0.001, respectively]. Unlike results of a few previous studies on this issue, no significant differences were found between the two groups. It is recommended that future assessments study should be done on broader populations and should be considered behavioral and psychological dimensions
ABSTRACT
Echinococcosis remains a significant health hazard in endemic areas, including the Middle East, Mediterranean countries and Central Asia. Pulmonary disease appears more commonly in younger individuals but bilateral pulmonary involvement is relatively rare. Concomitant pulmonary and liver hydatid disease may occur in 4% to 25% of patients with hydatidosis. A previously healthy 20-year-old femal from north of Iran without any previous history of lung or liver disease presented with complaints of right upper quadrant and right side chest pain and a low grade fever for the past one month. In imaging studies, one cyst in the left lung, two cysts in the right lung and two cysts in the liver were found. Since the cysts were symptomatic, it was decided to treat these cysts surgically. The patient underwent bilateral anterolateral thoracotomies and phrenotomy under general anesthesia and all cysts were evacuated. The patient was discharged in good condition