ABSTRACT
Background: environmental pollutants affect various tissues. Bisphenol A, a compound used in making epoxy resins and polycarbonate plastics, induces many hazardous effects
Aim of the work: this work was designed to test the ameliorative potential of selenium against hepatotoxicity caused by bisphenol A
Materials and Methods: male rats were divided into four groups. Group 1 served as control, group 2 given sodium selenite, group 3 was administered with suspension of bisphenol A that is dissolved in corn oil. Rats of group 4 were administered with selenium plus bisphenol A. Liver specimens and blood samples were inspected after 3 and 6 weeks of treatment
Results: there was no statistical difference between control and selenium -administered rats in all parameters. Rats treated with bisphenol A suffered significant depression in weight whereas selenium administration decreased the effect on rat's weight. Bisphenol A administration induced blood vessels congestion, inflammatory infiltration, bile duct proliferation, cytoplasmic vacuolization and macrosteatosis while selenium administration improved liver histopathological criteria either after 3 or 6 weeks. Bisphenol A treatment elevated nuclear PCNA and caspase-3 expression in the cytoplasm and liver function enzymes [serum AST and ALT] and bilirubin. Again, selenium ameliorated these changes. In conclusion, bisphenol A exerted deleterious impact on rats' hepatocytes and serum biochemical parameters in a time-dependent manner. Selenium supplementation provides an extent of amelioration against bisphenol A- induced hepatotocixity