ABSTRACT
Simultaneous recording of electroencephalogram (EEG)-functional magnetic resonance imaging (fMRI) plays an important role in scientific research and clinical field due to its high spatial and temporal resolution. However, the fusion results are seriously influenced by ballistocardiogram (BCG) artifacts under MRI environment. In this paper, we improve the off-line constrained independent components analysis using real-time technique (rt-cICA), which is applied to the simulated and real resting-state EEG data. The results show that for simulated data analysis, the value of error in signal amplitude (Er) obtained by rt-cICA method was obviously lower than the traditional methods such as average artifact subtraction ( <0.005). In real EEG data analysis, the improvement of normalized power spectrum (INPS) calculated by rt-cICA method was much higher than other methods ( <0.005). In conclusion, the novel method proposed by this paper lays the technical foundation for further research on the fusion model of EEG-fMRI.
ABSTRACT
Objective To evaluate whether the stimulation on eyes of bendazac lysine eyedrops could be reduced by cold storage.Methods Mate design scheme and double-blind clinical trial were performed. 160 healthy eyes was divided into two groups: the test group was given bendazac lysine eyedrops which was stored in refrigerator at 4℃ over night, and the control group was given it which was stored at room temperature.Results ln the control group and the test group, the occuring rate of stimulation was 19.30% and 6.25%. The cases of B、C stimulation degrees were 31 and 10; the average stimulation degrees of each group were 1.21 and 1.07, the scoring change for eye stimulation were 1.57±1.50,0.79±1.40,all respectively. The statistical difference was significant (P＜0.05 or P＜0.01).Conclusion The eye stimulation of bendazac lysine eyedrops can be reduced by cold storage.
ABSTRACT
The infrastructure of in vitro cultured exoerythrocytic stage (EE) of Plasmodium ber-ghei (P.b.)was observed under transmission electron microscope (TEM).The drug sensitivity of EE was also measured in vitro.The EE was cultured in monolayer host cell,fixed and embeded in situ.The ultrathin sections were prepared and examined by routine methods.The TEM pictures showed that the fine structure of in vitro cultured EE was similar with that of EE grown in rat hepatocytes in vivo,as described by Meis et al.The parasite was found within a parasitophorous vacuole,with nucleus,mitochondria,endoplasmic reticuia and Golgi apparatus were observed inside the parasite.After 24h cultivation,the EE was incubated for 48h in medium containing a serial concentrations of primaquine or chlo-roquine,then examined under light microscope.The percentage of abnormal parasites was calculated.The preliminary results showed that the sensitivity of cultured P.b.EE to primaquine and chloroquine was significantly different.At the same concentration of 1?10-5 mol/L,the percentage of abnormal parasites was 38.5?3.9% and 5.7?1.9% ,respectively These results demonstrated that the in vitro cultivation system of P.b.EE would have potential utility in antimalarial drug research.(Figs.1-6)