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Objective To evaluate the efficacy and safety of CT-guided 125I radioactive seed implantation combined with gemcitabine and Gio (gemcitabine and S-1, GS scheme) chemotherapy in treating advanced pancreatic carcinoma. Methods Sixty-eight patients with inoperable advanced pancreatic carcinoma were randomly divided into two groups. Patients in group A(n=38) were treated with CT-guided 125I radioactive seed implantation combined with GS chemotherapy scheme, while patients in group B (n=30) received GS chemotherapy scheme only. The short-term effect, the median progression-free survival time, the median survival time and adverse reactions of the two groups were determined , and the results were compared between the two groups. Results The objective response rate (ORR), disease control rate (DCR) and clinical benefit rate (CBR) of the group A were 57.9%, 73.7%and 84.2%respectively, while those of group B were 26.7%, 46.7% and 60.0% respectively. The differences between the two groups were statistically significant (P0.05). Conclusion For advanced pancreatic carcinoma, CT-guided 125I radioactive seed implantation combined with GS program is a safe and effective treatment.
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Objective To investigate the value of CT-guided 125I particles implantation combined with gemcitabine plus S-1 (GS) regimen in the treatment of locally advanced pancreatic cancer.Methods 42 patients with unresectable local advanced pancreatic cancer were given with CT-guided 125I seed implantation.3-4 cycles of GS regimen was given based on the tolerance of patient s body within 3-7 d after implantation of particles.Review of blood,CA199,chest X-ray,CT scan + enhanced or MRI were performed at 2nd,4th,6th,12th month after surgery.Results 2nd,4th,6th month after surgery,tumor lesions were significantly reduced,ORRs were 59.5 ％ (25/42),66.7 ％ (28/42) and 73.8 ％ (31/42),respectively,DCRs were 83.3 ％ (35/42),78.6 ％ (33/42) and 76.2 ％ (32/42),respectively.No serious adverse reactions were observed,patient could tolerate these reactions.The 6th,12th,24th month survival rates were 100 ％ (42/42),47.6 ％ (20/42) and 11.9 ％ (5/42),respectively,mPFS was 8.27 months and mOS was 12.00 months.Conclusion CT-guided 125I particles implantation combined with GS regimen is convenient,safe,high efficacy in the treatment of locally advanced pancreatic cancer.
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Objective To improve the knowledge of lumbar posterior marginal cartilagionous node.Methods CT findings of lumbar posterior marginal cartilaginous node in 52 cases were analyzed.Results Three CT characters were:summarized cartilagionous node,centrum posterior marginal osseous absence and protruding follicle ring fragment.Conclusion CT scanning hes defiuite diagnositic value for the lumbar posterior marginal cartilaginous node.
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Objective To improve recognition of the processus articularis arthropathy.Methods CT findings of the processus articularis arthropathy was analysed.Results According to the CT findings of the 94 cases processus articularis arthropathy,CT signs and the syndrome of this disease were summarized five types:①zygapophyseal hypertrophy and osteophyte formation;②stricture or asymmetry of articular space ;③vacuum phenomenon of articular space ;④pachynsis or calcification of articular capsule ;⑤articular instability.Conclusion The processus articularis arthropathy is a very high incidence of a disease.The CT scanning is very important significance to the disease.
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Objective To discuss the diagnostic value of the lumbar intervertebral disc degeneration by CT scanning.Methods The clinical representation and CT view of 809 cases with degenerative lumbar intervertebral disc were retrospectively analyzed.Results According to the different CT representation character,the degenerative lumbar intervertebral disc may be divided into the lumbar intervertebral disc denaturation bulge in 96 cases and the lumbar intervertebral disc herniation in 713 cases.Conclusion CT scanning is a value method to diagnosing degenerative lumbar intervertebral disc.
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Objective To study the value of common X-ray and CT scanning in the spinal bursting fracture (abridged English:BF).Methods By the frontal,lateral X-ray film and CT scanning,the imaging manifestations of BF in 43 cases were analysed,contrasted,summarised and classified .Results Among the BF 43 cases,the classifications were type A(10 cases),type B(15 cases),type C(2 cases),type D(9 cases) and type E(7 cases).The three-post injure had 34 cases,the two-post injure had 9 cases,the spinal canal narrowing:0?was 8 cases,1?was 12 cases,2? was 23 cases;the rear spinal edges discontinuation was 35 cases.Conclusion The diagnostic value of X-ray film to BF is reflecting the bones injured change of spinal fracture type,flexion and damaged rear edge.The CT scanning advantage is showing the fracture lines trend,relative scope,degree of spinal canal deformation and narrow,infering the pressed situation and injured spinal cord.The two methods combine and confirm each other in order to help clinical diagnosis the right treating.