2-Hydrazinopyiimidines as precursors for azolopyrimidines and pyrimidotriazines expected antimicrobial activity

Reaction of 2-hydrazino derivatives 2a,b with aromatic aldehydes afforded the arylhydrazone derivatives 3a-c which cyclized into triazolo derivatives 4a-c. Furthermore 2a,b reacted with aliphatic acids namely formic acid and acetic acid to yield the corresponding triazolo derivatives 5a-c and with nitrous acid to give the tetrazolo derivatives 6a,b. Compounds 6a,b were reduced by zinc dust to yield amines 7a,b. Also, compounds 2a,b reacted with carbon disulphide to yield the 3-triazolothione derivatives 8a,b. On the other hand, 2-hydrazino compounds 2a,b condensed with ethyl acetoacetate to afford 2-ethylacetoacetatdiydrazon derivatives 9a,b. Compound 9a cyclized by heating in ethanolic sodium ethoxide to yield 2-[l-pyrazolyl] derivative 10. Furthermore, compounds 2a,b reacted with phenacyl bromide to give triazinone derivative 11 and condensed with pentane-2, 4-dione to yield pyrazolyl derivatives 12a,b. Newly synthesized compounds 2b,5b,6b,7b and 9b exhibited promising biological activity

Racial variation in clinical characteristic and outcome in patients presenting with acute myocardial infarction: comparison between Qatari and South Asian patients in Qatar

South Asians [SA] from the Indian Subcontinent are known to have coronary artery disease [CAD] at a very young age and also to have a more diffuse disease when compared to indigenous patients in the Western world. The aim of the study was to compare clinical characteristics and outcome of South Asian patients to Qatari patients presenting with acute myocardial infarction [AMI] in Qatar. The majority of SA residing in Qatar are manual workers of lower socioeconomic status when compared to the Qatari population. We conducted a retrospective analysis of a prospectively collected data of all patients diagnosed with acute myocardial infarction [AMI] in the State of Qatar during ten years [1991 -2001]. Patients were divided into two groups: Qataris [1598 patients] and South Asians [2606 patients]. Diagnostic classification of definite AMI was made in accordance with criteria based on the International Classification of Disease ninth revision [ICD-9]. The obtained information was based on the following parameters: age at the time of admission, gender, cardiovascular risk factor profiles [smoking, hypercholesterolemia, diabetes, and pre-existing coronary heart disease], and ECG. Data analyses were performed using univariate and stepwise logistic regression analysis. When compared to Qatari patients, SA patients were younger [47 yrs vs 61 yrs; p < 0.0001]. SA were more likely to be smokers [50.5% vs 23.4%; p < 0.0001] and male [96.9% vs 71.8% p < 0.0001]. SA were less likely to have: diabetes mellitus [24.8% vs 54.0%; p < 0.0001]; hypertension [19.9% vs 37.6%; p < 0.0001]; previous MI [8.1% vs 15.8%; p < 0.0001]; CABG [2.2% vs 3.9%; p = 0.002]. The number of patients who received thrombolytic therapy was significantly higher among SA when compared to Qatari [54.6% vs 25.9%; p < 0.0001], and this was significantly associated with lower in-hospital mortality rate [6.7% vs 16.8%; p < 0.0001]. SA patients who had AMI in Qatar had better outcome than Qataris. This may be explained by the patients' favorable baseline clinical characteristics such as younger age and less prevalence of diabetes and hypertension

Tuberculoma of the spermatic cord

Objective and importance: Tuberculoma of the intrascrotal cord is rare. There were only 8 other cases reported in the English literature. Clinical presentation: A 40-year-old man presented with a painless mass in the left scrotal region. Preoperated frozen section showed it to be a tuberculous lesion. Intervention or technique: The mass was excised in toto and the final histopathology confirmed the frozen section and antituberculous drugs were administered. An awareness of this condition would prevent an orchidectomy on the patient for a benign lesion

Cutaneous cautery in sciatica

We describe five cases of cutaneous cautery in patients with chronic sciatica. The cautery was used as a traditional therapy when modern conservative treatment had failed. in all cases, intervertebral disc prolapse was later confirmed and, in four cases, operated on with good results. Cutaneous cautery is an alternative medicine that does not cause lasting improvement of the symptoms of sciatica However in such cases, the presence of the scars resulting from cautery constitute useful signs indicating genuine symptoms, chronicity and, possibly, assist in localising the level of the disc lesion. Cautery is a possible index for patient selection and an indicator of subsequent success should operative treatment be elected