ABSTRACT
Ultrasound (US), traditionally a diagnostic modality, and is emerging as a non-invasive therapy using local drug delivery and gene therapy. US exposure gene rates bio eff ects that result in shear stress, tissue heating, and cavitation eff ects, which are used in therapeutic applications. Sonoporation employs these eff ects to enhance delivery of large molecules such as DNA into the cells which is applied to muscle, head and neck tumor, in a cell disruption process called transformation and increases the permeability to bioactive materials, which is usually used in molecular biology and gene therapy. Nevertheless, it has recently become popular as a technique to enhance drug release from drug delivery systems. Th is review presents the main fi ndings in the fi eld of sonoporation, namely drug delivery, gene delivery and DNA transfer and its applications in dentistry.