ABSTRACT
Objectives: To determine the diagnostic accuracy of perfusion CT in grading gliomas taking histopathology as gold standard
Study design: Cross-sectional validation study
Setting: Department of Radiology, Allied/DHQ Hospitals, Faisalabad
Period: Study was carried out over a period of six months from 01-09-2015 to 28-02-2016
Methodology: A total of 105 patients were included in this study. Low radiation dose non contrast CT head was performed to localize the region of interest before obtaining a perfusion scan. For the perfusion scan, 50ml of non ionic contrast is injected at a rate of 4-5ml/sec through an IV line by using an automatic power injector. At 5 seconds into the injection, a cine scan was initiated with the following technique: 80kv,100-120mA and 1 second/ rotation for a duration of 50 seconds. After the initial 50 sec cine scan, 8 more axial images were required, 1 image every 15 seconds for an additional two minutes, thus giving a total acquisition time of 170 sec to assess delayed permeability showing a large heterogeneous lesion with surrounding edema and mass effect on CT brain plain were included in the study
Results: Mean age of the patients was 49.4 +/- 16.1 year. There were 69 males [65.7%] and 36 females [34.3%]. Comparison of perfusion CT findings versus histopathology in diagnosing high grade gliomas showed positive cases 77 and 95, respectively. Sensitivity, specificity, diagnostic accuracy, positive predictive value and negative predictive value of perfusion CT was 78.9%, 80.0%, 79.0%, 97.4% and 28.6%, respectively
Conclusion: In conclusion, clinically available perfusion imaging tools by using CT can provide additional information regarding brain tumor vascular estimates, which could be useful imaging biomarkers for preoperative glioma grading and angiogenesis assessment and could also be useful for treatment planning and response assessment
ABSTRACT
Objectives: To determine the correlation between higher total cholesterol level and high Barthel Index score in patients with acute ischemic stroke
Methodology: This cross sectional study was conducted at Radiology department and Medical Unit 1, Allied Hospital, Faisalabad for duration of 6 months from January 2015 to June 2015. 200 patients were included through Consecutive [non-probability] sampling technique. All the patients were undergone CT scan Brain from the radiology department of the Allied hospital to determine the respective changes [hypo dense area] of the ischemic stroke. Fasting serum cholesterol was measured in all patients after an overnight fast of 12 hours by drawing blood through 5cc BD syringe by me. Then all the patients were assessed by using Barthel Index score [BI]. Higher total cholesterol and high BI score were labeled after assessing the laboratory and clinical findings. The data was analyzed by using SPSS version 17.0. Spearman Rank correlation coefficient was calculated to BI score in patients with ischemic stroke. P-value<0.05 was considered as significant
Results: The mean age of the patients was noted as 61.76 +/- 11.55 years. In this study 55.50% were males and 44.50% patients were females. The mean total cholesterol value of patients was noted as 251.59 +/- 71.15 mg/dl. Out of 200 patients, 112 [56%] patients had high cholesterol [>200mg/dl] whereas 88 [44%] patient had low cholesterol of [<200mg/dl]. In this study the results showed that the mean value of total Barthel index score was 57.50 +/- 19.52. The study results described that 103 [51.50%] patients had high Barthel index score [>53] whereas 97 [48.50%] patients had low Barthel index score [<53]. Spearman correlation coefficient was calculated between high TC and high BI score as r= 0.631. This value was statistically significant i.e. p-value=0.000
Conclusion: With the help of this study, we found a significant positive relationship between high TC and high BI score in patients presented with ischemic stroke. Now we can better prognosticate the functional outcome of ischemic stroke in our patients
ABSTRACT
Objectives: To determine the frequency of carotid atherosclerosis in obese patients having hepatic steatosis and its effect on the development of MI. Design: Cross sectional study. Setting: Department of Radiology Allied Hospital, Faisalabad. Period: From January 2012 to June 2013
Patients and Method: A total of 96 patients were included in this study. LOGIC 5 Doppler ultrasound machine was used. B-mode ultrasonography of common carotid arteries was performed on both sides with a 7.5 MHz linear array transducer. Ultrasound was done in supine position and elevation of chest by pillow. Patient head will be turned to the opposite side. Intima media thickness was accessed in the distal wall of common carotid artery of both sides 1.0 cm proximal to carotid bulb
Results: Mean age of the patients was 46.69 +/- 11.86 years. Out of 96 patients, 51 [53.1%] were males while remaining 45 patients [46.9%] were females. Presence of carotid atherosclerosis was noted in 96 patients [100.0%]. Out of these patients, myocardial infarction was present in 81 patients [84.4%]. Mean BMI was 30.67 +/- 0.47, mean weight was 91.86 +/- 7.57 Kg and intima media thickness was 0.84 +/- 0.12 mm
Conclusion: Prevalence of atherosclerotic changes in carotid arteries detected by Doppler ultrasound among obese patients having hepatic steatosis and its effect on the development of MI is remarkable