ABSTRACT
Sickle cell anaemia is one of the major types of anaemia found in Sudan; especially in western Sudan in which the sickle cell gene is frequent. This study estimates the prevalence of sickle cell anaemia in other areas rather than western Sudan where it is more prevalent (Algadaref state). 100 blood samples of blood were taken from differenttribes (eleven tribes) living in the northern area of Algadaref state. 24 samples were collected from urban area; 76 from rural area; all tribes originated from Afro-Asiatic speaking regions. All samples were tested for complete blood count (CBC); and haemoglobin electrophoresis. The study revealed that the majority of sickle cell anaemia cases was found among the Masaleet tribe. 20 samples were (Hb-SS); 55 samples were (Hb- AS) and 25 samples were (Hb -AA)