ABSTRACT
This study was conducted on 30 patients with hepatocellular carcinoma [Hcc-3-6 cm in the largest diameter].They were divided into two equal groups: The first group was treated by a single or multiple sessions of percutaneous ethanol injection, while the second group was treated by a single or multiple sessions of percutaneous acetic acid injection. All patients were subjected to full history takings clinical examination, and routine laboratory investigations including alpha feto-protein. Radiological assessment was carried out using abdominal ultrasonography and triphsic computed tomography. The patients were clinically followed up and assessed at one, and three months after therapy by abdominal triphasic computed tomography, ultrasound and alpha feto-protein [AFP]. There was no significant difference between the studied groups as regard age and sex distribution or the clinical features. Hepatomegaly was detected in 4 [26.7%] in groups I and II. Splenomegaly was detected in 10 [66.7%] in group I and 11[73.3%] in group II. No ascites was detected by shifting dullness in all patients of both groups. Regarding the ultrasonographic criteria, 24 [80%] patients had their focal lesions in the right lobe. Most of the focal lesions were from 3-4 cm in diameter 24 [80%], mostly hypoechoic [85%]. Also, the diameter of focal lesions increased in 10 [66%] patients of group I in comparison to 12 [80%] patients of group II. Spiral CT one month after the procedure showed complete ablation was achieved in 10 patients [66.7%] of group I and in 13 patients [86.7%] of group II. Although percutaneous acetic acid injections showed higher rate with complete ablation, the difference was not statistically significant in comparison with the other group