ABSTRACT
The aim of this study is to evaluate meta-iodo-benzyl-guanidine scintigraphy in the diagnosis and the management of neuroblas-toma. betwen September 1999 and jun 2004, 16 children aging from 4 months to 6 years, with neuroblastoma, underwent mlBG scintigraphy in military hospital nuclear medicine department. 23 mlBG scans were done. The exam was indicated for the initial staging in 7 cases, to evaluate chemotherapy or surgery in 12 cases and to seek for reccurences in 3 cases. The sensitivity of mlBG was 57% in the detection of the primary tumor, 100% for liver metastases and 67% for medullar involvement. mlBG scintigraphy should be a standard in the initial staging of neuroblastoma and in evaluating therapy response
ABSTRACT
The aim of this study is to evaluate the accuracy of scintigraphie preoperative localization of abnormal parathyroid gland. 25 patients with confirmed hyperparathyroidism undergone scintigraphie and ultrasound localization prior to surgery. Paratthyroid scintigraphy was done with thallium - techetium substraction and technetium-tetrofosmin dual phase techniques. scintigraphie sensitivity and specificity was 83% and 100%. In primary hyperparathyroidism the sensitivity was 91% vs 75% in secondary one. Multinodular goiter affected sensitivity [72%]. Ultrasound had an overall sensitivity of 66% and a specificity of 100%. parathyroid scintigraphy is non invasive, accurate and costeffective in localizing abnormal parathyroid gland especialy adenoma
ABSTRACT
The objective of this work is to evaluate a new therapy, the metabolic radiotherapy to the 153Samarium-EDTMP, of recent introduction in Tunisia, in the painful bony metastasis treatment observed at the patients affected of cancer of the prostate. It is about a retrospective survey with a receding of 40 months, achieved through 45 files of patients having benefited all of this new treatment for painful bony metastases in relation with a prostatic adenocarcinoma and collected by three centers of Nuclear Medicine of the capital: the institute Salah Azaiez [state-controlled], the Center CERU [deprives] and the Military hospital [HMPIT]. We tried to appreciate essentially four parameters: UV, therapeutic efficiency, the factors influencing the answer h the treatment, the toxicity of the treatment and the sources of failure. We observed a positive answer in 92,1% of the cases, this answer was complete in 36,5% of the cases. The results gotten after multiple administrations show that the cures could be repeated with results comparable to those of the first cure. The therapeutic efficiency is at least equivalent to those of the other therapeutic means, with nearly non-existent secondary effects. The only toxicity is of hematological order; it is the most often moderate and reversible with a complete recuperation at the end of 8 weeks. Besides, the effect on the pain came with an improvement of the quality of life of the patients treaties. Its precocious introduction in the taken in charge of the metastatic patients, would allow them to benefit better from its efficiency, simplicity and weak toxicity and therefore to enjoy a better quality of life