ABSTRACT
Aim: The aim was to compare the effects of dexmedetomidine and remifentanyl in total intraveous anesthesia [TIVA] in laparoscopic cholecystectomy operations
Methodology: Forty, 18-60 years old, elective laparoscopic cholecystectomy patients were included in the study. In Group D, TIVA was performed by 150 microg/kg/min propofol and 0.5 microg/kg/h dexmedetomidine infusions. In Group R patients, TIVA was performed with 150 microg/kg/min propofol and 0.5 microg/kg/min remifentanil infusions. Systolic blood pressure, heart rate, SpO[2], end tidal CO[2] were recorded. All infusions were terminated at the end of surgery. Adequate spontaneous respiration, extubation, and response to verbal commands; and Aldrete score >/= 9 times, postoperative pain scores and vital parameters in the postoperative period were recorded. Patient-controlled analgesia pump was used in all postoperative patients. Total analgesic consumption, patients' first analgesic needs were recorded
Results: Intraoperative Systolic blood pressure, diastolic blood pressure and heart rate values remained significantly lower in remifentanyl group compared to those in dexmedetomidine group [p < 0.05]. First postoperative analgesia time was shorter and hemodynamic parameters were significantly higher in this group [p < 0.05]. Postoperative recovery of dexmedetomidine group remained more stable in terms of VAS values [p < 0.05]
Conclusions: Remifentanil provides a potent intraoperative anesthesia compared with dexmedetomidine; however, dexmedetomidine may be considered in TIVA as an option for a stable postoperative recovery