Glucose-6-phosphate dehydrogenase [G6PD] deficency in neonates presenting with Jaundice

To determine the frequency of Glucose-6-phosphate dehydrogenase [G6PD] deficiency in infants presenting with jaundice. This retrospective study was conducted in Fazal Rahim Clinical Laboratory Timergara District Dir North West Frontier Province of Pakistan, from 1st January 2004 to 31st December 2004 on 120 neonates. Data regarding sex and age, serum bilirubin total, serum bilirubin direct and G6PD status was extracted using database software designed by the principal author. The inclusion criterion was neonates with high serum bilirubin and G6PD test performed simultaneously. The exclusion criterion was premature babies and incomplete request forms. Microsoft Excel 2000 was used for data analysis Out of 120 patients, 97 [80.8%] were male and 23 [19.2%] were female ranging in age from 3 - 10 days with mean 6.5 days and median 5 days. Thirty two [26.6%] neonates were found G6PD deficient. Among patients with normal G6PD level male to female ratio was 3.63:1. In G6PD deficient patients male to female ratio was 7:1. The serum bilirubin of the G6PD normal patients was 12.8 + 5.0 mg/dl and that of G6PD deficient patients was 13.5 + 6.8 mg/dl. G6PD deficiency is quite high in neonates presenting with jaundice. The diagnosis is simple and if left undetected may cause serious consequences in situations of oxidant stress

Frequency of nephrotic syndrome in children

To find out the frequency of childhood nephrotic syndrome and its relation to different solar months. Material and This study was conducted in paediatrics department of Postgraduate Medical Institute, Lady Reading Hospital, Peshawar from 1st August 1995 to 31st July 1996. All children with proteinuria and oedema were studied. All children were thoroughly examined and investigated. Total number of admissions due to various diseases were 3441. Out of these 61 [1.8%] children fulfilled the criterion of childhood nephrotic syndrome. Number of admissions varied in different solar months. 3 [4.9%] cases were admitted in August, 6 [9.9%] in September, 4 [6.5%] in October, 3 [4.9%] in November and December each, 10 [16.4%] in January, 6 [9.9%] in February and March each, 7 [11.5%] in April, 5 [8.2%] in May, 7 [11.5%] in June and 1 [1.6%] in July. Five [8.2%] children were in age range of 1-2 years, 27 [44%] were in age range 2-6 years, 17 [27%] in age range of 6-8 years and 12 [19.2%] above 8 years of age. Nephrotic syndrome is fairly common in children with male preponderance. Most admission due to nephrotic syndrome were in the month of January