ABSTRACT
Background: Genetic and environmental factors are known to be risk factors in development of neovascular age-related macular degeneration [nAMD]. Genetic factors such as polymorphisms in the complement component pathway genes might play a role in pathogenesis of nAMD and has been studied in various populations excluding Malaysia
Aim of the study: To determine the association of the R102G polymorphism of the complement component [C3] gene in nAMD subjects
Patients and methods: A total of 301 Malaysian subjects [149 case and 152 controls] were recruited and genotyped for the R102G [rs2230199] variant of the C3 gene. Genotyping was conducted using the PCRRFLP method and association analysis was conducted using appropriate statistical tests
Results: From our findings, no significant association was observed in the allele distribution of C3 R102G between nAMD and controls [OR = 1.42, 95% CI = 0.77-2.62, P = 0.268]. A further analysis that compared three genetic models [dominant, recessive and co-dominant] also recorded no significant difference [P > 0.05]. These findings could be due to the low frequency of the GG variant in the case [4.7%] and control [1.3%] groups, compared to the normal variant CC, which is present in 91.3% of case and 92.8% of control alleles
Conclusion: The present study showed no evidence of association between C3 R102G polymorphism and nAMD in Malaysian subjects
ABSTRACT
Orbital compartment syndrome (OCS) is a visual threatening ocular emergency. We report a 50-year-old male with acute presentation of OCS, a rare manifestation of idiopathic orbital inflammatory disease. At presentation, high intraocular pressure was reduced by prompt lateral canthotomy and cantholysis. The disease responded to systemic steroids and treatment resulted in good visual outcome. Detail evaluation and early detection and treatment are mandatory to prevent permanent vision loss.