ABSTRACT
OBJECTIVE@#To analyze the main factors affecting the positive results of acupuncture for chronic pain in English literature of randomized controlled trial (RCT), in order to provide reference for the design of acupuncture clinical research.@*METHODS@#The RCTs of acupuncture for chronic pain published before March 26, 2020 were searched in PubMed, EMbase and Cochrane Library by computer. A total of 21 factors were analyzed by single-factor analysis, and the factors with statistically significant difference were selected for multivariate Logistic regression analysis.@*RESULTS@#A total of 69 RCTs were included, including 47 RCTs (68.12%) with positive results and 22 RCTs (31.88%) with non-positive results. The multivariate Logistic regression analysis was performed with the three screened factors (publication year, treatment frequency and intervention form) selected by single-factor analysis, and the results showed that the positive results were related to the frequency of acupuncture treatment. The positive rate of RCT with frequency≥2 times a week was 3.24 times of that with frequency<2 times a week (OR=3.24, 95%CI =[1.07,9.83], P<0.05).@*CONCLUSION@#Acupuncture frequency may be the main factor affecting the positive results of RCT in English literature of acupuncture for chronic pain. More researches are needed in the future to explore the influence of acupuncture frequency on the curative effect.
Subject(s)
Humans , Acupuncture , Acupuncture Therapy , Chronic Pain/therapy , PubMedABSTRACT
OBJECTIVE@#To observe the clinical effect of acupuncture at "experienced ten acupoints" for postprandial distress syndrome.@*METHODS@#A total of 62 patients with postprandial distress syndrome were randomly divided into an observation group (31 cases, 5 cases dropping off) and a control group (31 cases, 6 cases dropping off ). Acupuncture was applied at Baihui (GV 20), Zhongwan (CV 12), Qihai (CV 6), Tianshu (ST 25), Neiguan (PC 6), Zusanli (ST 36), Gongsun (SP 4), Danzhong (CV 17) in the observation group. In the control group, 6 non-acupoint points were intervened with shallow puncture. The treatment was given 20 min each time, once every other day, 3 times a week for a total of 4 weeks in the two groups. Symptom index of dyspepsia (SID) and Nepean dyspepsia index (NDI) scores were compared before and after treatment, and the efficacy was evaluated in the two groups.@*RESULTS@#The effective rate in the observation group was 76.9% (20/26), which was higher than 28.0% in the control group (7/25, <0.01). After treatment, the SID and NDI scores in the two groups were lower than those before treatment (<0.01, <0.05), and the SID and NDI scores in the observation group were lower than those in the control group (<0.01, <0.05).@*CONCLUSION@#Acupuncture at "experienced ten acupoints" can significantly reduce the symptoms of dyspepsia and improve the quality of life in patients with postprandial distress syndrome.
Subject(s)
Humans , Acupuncture Points , Acupuncture Therapy , Methods , Dyspepsia , Therapeutics , Quality of Life , Syndrome , Treatment OutcomeABSTRACT
MicroRNAs (miRNAs) are a class of small non-coding RNA which exert post-transcriptional gene regulation activity by targeting messenger RNAs. miRNAs have been found involved in a great variety of fundamental biological processes, and deregulation of miRNAs is known to be closely related to morbidity. Recent studies have confirmed that severalmiRNAs were differentially expressed after renal ischemia-reperfusion injury (IRI), and some of them might be involved in IRI regulation. miRNAs can influence the expression of inflammatory mediators in endothelial cells, dendritic cells and macrophages, and thus regulate inflammatory response during renal IRI. miRNAs might also influence genes related to apoptosis and proliferation, and thus regulate apoptosis and proliferation of tubular epithelial cells. miRNAs could also induce accumulation of endothelial progenitor cells in renal tissue and facilitate angiogenesis and injury repair. Extracellular studies have also showed that instant change of some miRNAs in serum and urine might reflect the degree of renal IRI. Therefore, miRNAs might serve as new biomarkers aswell as potential therapeutic targets for renal IRI.