ABSTRACT
AIM: To investingate the variety of the function of vascular endothelium in the patients with hypertensive nephropathy and the effect of Huayu Qinli Granule on (Hirudo,Rhizoma Smilacis Glabrae,Herba Leonuri,etc.) it. METHODS: This was a prospective,comparative and single-blind clinical trial.Patients in accord with the diagnosis and TCM differentiation standard were randomly divided into treatment group,united treatment group,blank control group and positive control group.Before the beginning of the trial,all patients were treated by Felodipine to lower their blood pressure to desired value.When the trial began,blank control group were treated only by Felodipine, positive control group were treated by general hypertension pills+captopril,treatment group were treated by Felodipine+Huayu Qinli Granule,united treatment group were treated by Felodipine+Huayu Qinli Granule+captopril.The course of study was for 4 weeks.The levels of urinary microalbumine(ALB),urinary ?_1-microglobulin(?_1-mg),urinary?_2-microglobulin(?_2-mg),serum nitric oxide and plasma endothelin were measured before and after the trial. RESULTS: The results showed both Huayu Qinli Granule and ACEI improved the levels of serum nitric oxide but there was slightly advantage over ACEI;both Huayu Qinli Granule and ACEI improved the levels of plasma endothelin,the improvement of Huayu Qinli Granule was(equal) to ACEI;united treatment group had the remarkable effect on serum nitric oxide and plasma endothelin. CONCLUSION: The results indicate that Huayu Qinli Granule improves the function of vascular endothelium in the patients with hypertensive nephropathy to a certain extent with the sufficiency of the treatment of depressing blood pressure.The effect of Huayu Qinli Granule is similar to that of ACEI.They cooperate with each other but mechanism of them may be different.
ABSTRACT
Objective To study the microstructural and ultrastructural changes of the epididymis of experimental varicocele in adolescent rats and it's role in infertility resulting from varicocele. Methods A varicocele model was performed in adolescent Sprague Dawley rats by partially ligating the left renal vein,the different segments of the epididymides of the rats were prepared for light and electron microscopy,the microstructure and ultrastructure of the epididymis were studied. Results There were lesions of different degree and segment specific changes in the epididymis with varicocele.Light microscopically,the main changes were interstitial vascular hyperemia,lymphocytes infiltration,sperm granuloma developed in the interstitial;The structure of the columnar epithelia was anomalies,epithelial cells degeneration,even the vacuoles appeared in the epithelial cells.The number of halo and clear cells increased.Inside the cavity of the duct,there were shedding cells,macrophage,deformed sperms and residual bodies.Electron microscopically,numerous large lysosomes,the residual bodies,the defected main cellular organelles(e.g. the endoplasmic reticulum,the mitochondrion and the Golgi complex etc.)and even large clear vacuoles were presented in the cytoplasm of principal cells.Clear cells were filled with lysosomes that made them frequently bulging into the lumen.The microvilli of the columnar epithelia were sparse and showed local defects.The thickness of the basal membrane increased.Conclusion\ The experimental varicocele in adolescent rats lead to microstructure and ultrastructure lesions in the epididymis,which may be another important reason of infertility resulting from varicocele.\;[