ABSTRACT
El objetivo de este estudio es determinar la magnitudy tendencia de las muertes por suicidio en el Uruguay enel período comprendido entre 1887-2010 y analizar sudistribución según edad, sexo y lugar de residencia. Es unestudio de tipo descriptivo con área en el territorio de laRepublica Oriental del Uruguay. Se trabajó con el total deluniverso de personas fallecidas por suicidio. En 123 años seobserva un aumento significativo de la tasa en todo el periodo(p < 0,05), en especial con aumentos bruscos en tiempos decrisis socioeconómicas, en estos últimos el mayor incrementose debe a Montevideo en relación al Interior del País. El sexomasculino presenta en el siglo XXI los valores más altos de lahistoria. (p < 0,05) La tasa presenta aumentos significativosen los grupos de edad de 15 a 34 años y en los mayores de65 años, en especial en el año 2002 y en 2010 (p< 0,05) Serecomienda profundizar y realizar el permanente seguimientodel Plan Nacional de Prevención de Suicidio aprobado porla Autoridad Sanitaria.
The objective of this study is to determine the quantity and characteristics of suicidesin Uruguay from 1887 to 2010 and analyze their distribution according to age, sex andplace of residence. This descriptive study is placed in the territory of the Oriental Republicof Uruguay. We worked with the total universe of people who committed suicide. In 123years there was a significant increase in suicide rate for the whole period (p <0.05), withdramatic increases in times of socioeconomic crisis. The most recent increase is observed inMontevideo in relation to other areas. In the twenty-first century men present the highestrates ever (p <0.05). The rate shows significant increases in the age group 15 to 34 and in theover 65 group, particularly in 2002 and 2010 (p <0.05). We suggest the continuous studyand follow up of the National Suicide Prevention Plan approved by the Health Authority.
Subject(s)
Humans , Male , Female , Suicide , Suicide/statistics & numerical data , Suicide/history , Uruguay/epidemiologyABSTRACT
The ability of purified plasma membrane glycoconjugates to inhibit the EDTA-resistant agglutination between aggregation-stage cells of Dictyostelium discoideum has suggested that receptor binding of these glycoconjugates provides a basis for cell-cell cohesion during aggregation. This has been tested by analysis of a series of mutants with different defects in the assembly of N-linked oligosaccharides. Mutant HL241 lacks outer branch components of N-linked oligosaccharides and fails to aggregate or express EDTA-resistant cohesion. HL244 makes unsulphated but otherwise normal N-linked oligosaccharides, generates multiple tips on aggregated cell mounds in some clones, and shows abnormally strong EDTA-resistant cohesion. Two mutants that are temperature-sensitive for complete processing of N-linked oligosaccharides are also temperature-sensitive for expression of both aggregation ability and EDTA-resistant cohesion. A revertant that recovered essentially normal N-linked oligosaccharide processing at the restrictive temperature has also recovered its ability to aggregate and to agglutinate in EDTA.