Associating microwave ablation and portal vein ligation for staged hepatectomy for the treatment of huge hepatocellular carcinoma with cirrhosis

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) could induce extensive and rapid future liver remnant hypertrophy. However, the morbidity for ALPPS is very high. This paper reports a modified ALPPS (associating microwave ablation and portal vein ligation for staged hepatectomy, AMAPS), which was successfully applied in the treatment of huge hepatocellular carcinoma with cirrhosis, and the procedure of operation was greatly simplified. Hence, AMAPS is feasible and safe in selected patients with primary hepatocellular carcinoma and cirrhosis.

Coffee consumption and pancreatic cancer risk: An update meta-analysis of cohort studies

Background and Objective: The results of epidemiologic studies on the relationship between the coffee consumption and pancreatic cancer risk were inconsistent. Thus, we performed an update meta-analysis of cohort studies to quantitatively summarize the association between coffee consumption and pancreatic cancer risk

Methods: We searched CBM [China Biology Medicine disc] and MEDLINE for studies of coffee consumption and pancreatic cancer risk up to June 2015. A total of 20 cohort studies were identified in this metaanalysis, and we analyzed these studies using random effects model. The dose-response analysis was conducted too

Results: The overall relative risk [RR] for highest coffee consumption versus lowest coffee consumption was 0.75 [95% Confidence Interval [CI], 0.63-0.86]. Statistic significant heterogeneity was found among these studies [I[2] =37.8%, P for heterogeneity =0.045]. The pooled RR for increment of 1 cup/day of coffee consumption was 0.99 [95%CI, 0.96-1.03] for the nine studies, without statistically significant

Conclusions: High coffee consumption is associated with a reduced pancreatic cancer risk. However, the result should be accepted with caution, due to the potential confounder and bias could not be excluded. Further well designed studies are needed to confirm the finding