ABSTRACT
Objective To investigate the influence of irbesartan and hydrochlorothiazide on the serum inflammatory factors (CRP ,IL‐6) ,Hcy ,endothelin and hemorheology levels in the patients with hypertension .Methods 148 cases of essential hyperten‐sion were divided into the research group (n=74) and the control group (n=74) according to the random grouping method .The control group was treated by the conventionally symptomatic therapy ,while on this basis the research group was given with the irbesartan and hydrochlorothiazide therapy .The total treatment course of 2 groups were 3 months .The systolic pressure and dias‐tolic pressure ,serum CRP and IL‐6 ,plasma Hcy ,endothelin levels ,hemorheology indexes in the two groups were performed the contrastive analysis .The drug safety was evaluated .Results The systolic pressure and diastolic pressure after the treatments in the two groups were significantly decreased compared with before treatment(P0 .05);the ser‐um CRP and IL‐6 levels after treatment in the research group were significantly lower than those in the control group(P0 .05);the plasma Hcy and endothelin after treatment in the research group were significantly lower than those in the control group(P0 .05) .Conclusion Irbesartan and hydrochlorothiazide can significantly reduce the blood pressure ,serum inflammatory ,Hcy and endothelins levels in the patients with hypertension ,have no influence on the he‐morheologic indexes and no serious adverse reactions ,and are safe and reliable .