Malignant teratoid medulloepithelioma of right eye in a child; a case report from first people's hospital of Jining city, China

Medulloepithelioma is a rare intraocular tumor, and it is also one of the most common congenital tumors originated in the epithelium of ciliary body. Since its onset hidden, it is often discovered after the invalid treatment of glaucoma, cataracts or strabismus. This paper will show you one case of malignant teratoid medulloepithelioma and combine with relevant literature review

Haemangiopericytoma: clinicopathological analysis of central nervous system

Hemangiopericytoma [HPC] in central nervous system is a rare tumor, his tumor has a high recurrence rate and the characteristics of extracranial metastases. Objectives:To investigate the clinicopathological features, imaging features, immunohistochemical phenotype of haemangiopericytoma [HPC] of central nervous system. Design: Hospital based crossectional prospective study. Period: From 24th October to 26th October 2012. Setting: First People's Hospital of Jining City, China. Methods: The clinical manifestations, imaging features, histopathological and immunohistochemical features were analyzed combining the review of the literature in one case of central HPC. Results: The Gross examination revealed the size of the tumor was 5cm × 4cm× 1.5cm; the section is gray, medium soft texture, and part of the area had capsule. The microscopic examination showed that the tumor cells were abundant and the same size, showing round, oval or short spindle shape. The cytoplasm was eosinophilic, and part of it was slightly translucent. The nuclei were ovoid, and the nucleoli were inconspicuous.A lot of capillaries lined by endothelial cells were seen in the tumor tissue, and the blood vessels were dilated like "staghorn" in some areas. Immunohistochemistry showed that tumor cells expressed Vimentin, CD34, CD99, Bcl-2, PR protein. They didn't express EMA, SMA, and S-100 protein. The proliferation index of ki-67 is about 4%. Conclusions: The central haemangiopericytoma is a rare tumor, having no specific clinical manifestations and imaging features. The final diagnosis requires a combination of histopathological and immunohistochemical examination, and it should be differentiated from meningioma, solitary fibrous tumor, hemangioblastomaandmesenchymal chondrosarcoma, etc.

Sclerosing epithelioid fibrosarcoma; a case report and review of literature

Sclerosing epithelioid fibrosarcoma [SEF] is a rare subtype of Fibrosarcomaandwas first reported in 1995. This tumour is rarely encountered and can easily be mistaken by clinicians for other diagnoses. This paper reports one case of SEF and review related literature. Objectives: To determine the clinical pathologic characteristics and discuss differential diagnosis of sclerosing epithelioid fibrosarcoma [SEF]. Methods: One case of SEF was studied by clinical analysis, light microscopy and the review of the literature. Results: The patient was an adult and had a tumor located in the subcutaneous tissue of the left leg, which was painless and grew slowly. Macroscopically, it was described as nodular and non-encapsulated. The cut section was gray-white, firm to elastic in consistency. The microscopic examination showed that the round to ovoid epithelioid cells with clear or eosinophilic cytoplasm arranged in cords, nests, sheets or alveolar pattern. The stroma showed a dense hyalinized collagenous background. Conclusions: Sclerosing epithelioid fibrosarcoma is a low-grade variant of fibrosarcoma, histologically, it should be differentiated from a variety of tumors which have the epithelioid appearance and sclerosing stroma

Intra-oral minor salivary glands neoplasms; the pattern and management

To determine the relative frequency and distribution of various types of intra-oral minor salivary gland tumours and their treatment modalities. Retrospective descriptive study. Muhimbili National Hospital [MNH], TANZANIA; at the department of Oral Surgery and Oral pathology. From 1993 to 2008. [16 years]. Hospital based data The information was retrieved from files and included; age, gender as well as their location, histological types and treatment modalities. Microscopic slides of all cases were reviewed and where necessary paraffin sections were re-cut and subsequently stained by haematoxylin and eosin. Special stained such as Periodic acid Schiff and/or mucicarmine were also performed in controversial cases. Tumours were classified according to the World Health Organization's Histological Typing of salivary gland tumours. Data were entered in the computer and analysed by SPSS. Statistical analysis was performed by student's t-test, and the difference were considered at 0.05 significance level. A total of 33 cases of intra-oral minor salivary gland tumours were studied. Out of these, 13 cases were benign and 20 were malignant. The male to female ratio for both benign and malignant tumours was 1:1.7. The age range for those with benign tumours was 16-78 years while for malignant ones was 17-76 years. Females were more affected than males in both benign and malignant neoplasms. There was a statistically significant difference in the mean age of occurrence of intra-oral minor salivary gland tumours in female compared to males [P=0.003]. With regard to the location of minor salivary gland tumours, the palate was the most affected site [51.5%]. Pleomorphic adenoma was the most frequent tumour located on the palate [52.9%] Similarly, the majority of malignant tumours were located on the palate [38%] followed by the Cheek [23.8%] and included adenocarcinoma, adenoidcystic carcinoma and mucoepidermoid carcinoma. Most malignant tumours were treated by adjuvant radiation therapy. Pleomorphic adenoma located on the palate was treated by excision with 1cm clinical margins at its periphery and including the overlying epithelium and periosteum. However, pleomorphic adenoma located on other mucosa sites was treated by peripheral excision with 1cm margin. With regard to monomorphic adenoma, conservative surgical excision including a rim or margin of normal uninvolved tissue was done. Palate was the common site for intraoral minor salivary gland tumours and that the percentage of the palatal cases were higher in benign than in malignant tumours. The mean age of occurrence of minor intraoral salivary gland tumours was higher in female patients than that of male patients