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1.
Chinese Journal of Medical Genetics ; (6): 198-200, 2002.
Article in Chinese | WPRIM | ID: wpr-245334

ABSTRACT

<p><b>OBJECTIVE</b>To explore the relationship between the methylenetetrahy drofolate reductase (MTHFR) C677T missense mutation and schizophrenia by linkage disequilibrium study.</p><p><b>METHODS</b>Linkage disequilibrium analys is was conducted bet ween MTHFR C677T and schizophrenia in 115 affected-sib-pair (105) and trios (10) families by XDT and MAPMAKER/SIBS soft system. The analyses were performed in different diagnostic categories and combined with the age of onset as well.</p><p><b>RESULTS</b>No positive results were found in the analysis in all the family in all the four diagnostic categories. Significant P values, which were P<0.05, P<0.01 respectively, were observed in the families with the affected individual's onset age less than 25 years in all the four diagnostic categories.</p><p><b>CONCLUSION</b>The missense mutation of MTHFR C677T or other gene structure around this mutation may be one of the susceptibility gene of schizophrenia.</p>


Subject(s)
Female , Humans , Male , DNA , Genetics , Family Health , Gene Frequency , Genotype , Linkage Disequilibrium , Methylenetetrahydrofolate Reductase (NADPH2) , Mutation, Missense , Nuclear Family , Oxidoreductases Acting on CH-NH Group Donors , Genetics , Schizophrenia , Genetics
2.
Chinese Journal of Medical Genetics ; (6): 6-9, 2002.
Article in Chinese | WPRIM | ID: wpr-245377

ABSTRACT

<p><b>OBJECTIVE</b>To explore the relationship between the microsatellite markers on chromosome 6 and schizophrenia by linkage disequilibrium analysis.</p><p><b>METHODS</b>Twenty-eight microsatellite markers on chromosome 6 were evaluated in 115 affected-sib-pair and trios families. Linkage disequilibrium analysis was conducted according to diagnostic categories, Positive and Negative Syndrome Scale (PANSS) and other clinical data by XDT and MAPMAKER/SIBS software system.</p><p><b>RESULTS</b>Significant P value (P<0.005) was found in all the four diagnostic categories. Only the locus of D6S1960 showed positive P value (P<0.05) in all the subgroups divided by PANSS scale and the age of onset.</p><p><b>CONCLUSION</b>The area around D6S1960 in short arm of chromosome 6 may contain susceptibility gene of schizophrenia.</p>


Subject(s)
Humans , Age of Onset , Chromosomes, Human, Pair 6 , Linkage Disequilibrium , Microsatellite Repeats , Genetics , Schizophrenia , Genetics
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