ABSTRACT
Coronary artery disease [CAD] refers to a lack of oxygen due to inadequate perfusion of the myocardium, which causes an imbalance between oxygen supply and demand. Many generalized or systemic risk factors predispose to development of atherosclerosis. Atherosclerosis of the coronary arteries commonly causes acute coronary syndromes. Adiponectin is one of the adipokines secreted by adipocytes. Adiponectin may play anti-atherogenic and anti-inflammatory roles. The aim of this study is to investigate whether concentrations of serum adiponectin constitute a significant coronary risk factor. Serum adiponectin was measured in 50 patients with CAD and in 20 control subjects. Patients were divided into three groups according to condition type: Acute myocardial infarction [AMI] group [n=20], unstable angina pectoris [UAP] group [n=15], and stable angina pectoris [SAP] group [n=15]. Serum concentrations of adiponectin in patients with CAD were significantly lower than in control subjects [p<0.000]. There was a significant negative correlation between adiponectin and triglyceride and significant positive correlation with HDL in patients. The findings suggest that measurement of serum concentrations of adiponectin may become a predictor risk factor for CAD and may be related to the development of acute coronary syndromes