ABSTRACT
Resumen Antecedentes: La menopausia se relaciona con cambios en la composición corporal que el uso de terapia hormonal (TH) puede revertir. Objetivo: Determinar el efecto de la TH parenteral y oral sobre la composición corporal en la menopausia. Material y métodos: Se realizó un estudio retrolectivo que incluyó a 86 mujeres de 45 a 55 años, con FSH > 20 Ul/ml, antecedente de histerectomía y sintomatología vasomotora, a las cuales se les administró TH por vía oral (44 pacientes) o parenteral (42 pacientes) durante seis meses. Se les realizó impedancia bioeléctrica antes y después del tratamiento. Resultados: La TH por vía oral se asoció con una disminución de diferentes parámetros de la composición corporal entre los que destaca la disminución de la grasa visceral (p < 0.05). La TH parenteral no mostró modificación en la composición corporal. Conclusión: La TH por vía oral modifica de manera positiva la composición corporal, lo cual puede contribuir a regular el estado metabólico.
Abstract Background: Menopause is associated with changes in body composition that the use of hormone therapy (HT) can reverse. Objective: To determine the effect of parenteral and oral HT on body composition in menopause. Material and methods: A retrolective study was carried out in 86 women aged 45 to 55 years old, with FSH > 20 Ul/ml, a history of hysterectomy and vasomotor symptoms. The participants received oral HT (44 patients) or parenteral (42 patients) for six months. Bioelectrical impedance was performed before and after treatment. Results: Oral HT was associated with a decrease in different parameters of body composition, among which the decrease in visceral fat stands out (p < 0.05). Parenteral HT did not show changes in body composition. Conclusion: Oral HT positively modifies body composition, which can help regulate the metabolic state.
ABSTRACT
Through many contributing factors (ethnicity, diet, exercise, sun exposure, sex, etc.), bone density has traditionally been considered to reach a peak (PBD), during the third decade of life. More recently, data suggests this might occur earlier, mostly mediated by onset and duration of sexual maturation. In order to ascertain such contention, we studied 45 young (20-24 yr) adults utilizing single-photon absorption densitometry (SPA, Norland 2870), at the distal 1/3 of non-dominant arms, a site with 75 per cent cortical bone. A uniform questionnaire on their life styles, ethnic/racial background, & biochemical/hormonal tests established their healthy state, as usually found among medical student volunteers. All had reached Tanner V stage. BD was obtained dividing BMC (bone mineral content, gm/cm) by BW (bone width, cm), and expressed as gm/cm2. Wt (weight) of Males (n = 24, age = 22.8 +/- 0.8 yr) was 77.9 +/- 8.9 Kg, height, (Ht) was 176.1 +/- 5 cm, both significantly higher than for Females (n = 21, Wt = 58.4 +/- 9.8 Kg, Ht = 159.2 +/- 5 cm), p < 0.0001). BMI (body mass index, kg/m2) were: M = 25.3 +/- 2.5 while F = 23.0 +/- 2.9 (p < 0.008). Ages were similar: M = 22.8 +/- 0.83, F = 22.5 +/- 0.81 years. Results were analyzed using SAS (IBM PS) & Cricket-graph (Macintosh), expressed as arithmetic means +/- SD or sem. LR (regressions) were applied whenever feasible.(ABSTRACT TRUNCATED AT 250 WORDS)