Prognostic markers after exacerbated chronic obstructive pulmonary disease. A new computerized multivariate algorithm

This study aimed to verify whether baseline clinical and laboratory parameters could predict the outcome for patients hospitalized due to acutely exacerbated COPD. To define the clinical and laboratory variables predictive of early mortality in patients with COPD, 50 consecutive admissions were studied, including 34 males and 16 female, with a mean age of 56 + 11 years. In all patients, demographic data, admission hemodynamics and arterial blood gases, mechanical ventilation, worst expressed as P02 <50 mun Hg PC02 /<30 or >/55 mum Hg and evident shunt P02/F102 /<200 were measured. The system for prognostication in patients with exacerbated COPD was based on a multivariate approach with staged trials using demographic data, admission hemodynamics and arterial blood gases. The study concluded that to allow prognostication in patients with COPD, a reasonable objective system was suggested for assessment, with a predictive accuracy reaching 96%. This system is characterized by being user-friendly, comprehensive and highly predictive

Prognostic markers in patients with systemic sepsis

The aim of the present study was to identify the prognostic factors that might distinguish survivors from non-survivors in patients with systemic sepsis and quantification of the severity of sepsis according to organ dysfunction [number and type]. Thirty-five patients with systemic inflammation response syndrome [SIRS] were included in this study. For all groups, the clinical and laboratory variables readings were chosen in on admission and at worst/highest reading. This study provided a simple scoring system based on the number of failing organs. Those who had more than three organs failure had significantly higher mortality compared with those who had less than three organs failing. Organs that were mostly predictive of mortality were neurologic, cardiovascular, respiratory dysfunction hematologic dysfunction