ABSTRACT
Aim of the work: residual kidney function [RKF] in end stage kidney disease [ESKD] patients contributes significantly to solute clearance. This improves survival as well quality of life in these patients. Kidney Diseases Outcomes Quality Initiative [KDOQI] guidelines suggest that hemodialysis [HD] dose can be safely reduced in those with RKF in the form of residual urea clearance [KRU] of 2 ml/min/1.73 m2 or more. However, measurement of RKU is difficult as it requires regular inter-dialytic urine collections. Simpler methods for measuring KRU and thus RKF are needed. Beta trace protein [BTP] has been proposed as alternative markers of RKF and RKU. Dialysis specific equations to estimate KRU based on serum BTP wererecentlydeveloped. This study aimed to compare measured KRU using inter-dialytic urine collection and estimated KRU using serum BTP
Patients and Methods: we included 60 ESKD patients in this study;they were divided into 2 groups. Group-1[G-1] had daily urine output <500ml and group-2[G-2] haddaily urine output >500ml. We estimated and measured KRU in both groups. Correlation between measured and estimated KRU in each group was done using Pearson correlation coefficient
Results: the estimated and measured KRU was strongly correlated in G-1 with r=0.746 at p<0.01, but it was week in G-2 with r=0.44 and p<0.05.Mean bias between estimated and measured KRU was 0.7 mL/min in G-1. In G-2 the mean bias was -0.54mL/min
Conclusion: KRU and thus RKF can be better estimated using serum BTP in patients with urine output >500mL than in patients with daily urine output200-500mL
ABSTRACT
Background: Cardiovascular disease [CVD] is not only deteriorating the quality of life of hemodialysis patients, but is also considered the main cause of death among them
Aim of the Work: This study was conducted to define the prevalence of symptomatic cardiovascular diseases and its risk factors among chronic kindey disease [CKD] patients on Hemodialysis [HD]
Patients and Methods: A total of 1000 CKD patients [stage 5] from10 HD centers in Cairo were enrolled in this study. Data was obtained in the form of a specially designed quetionnaire approaching 3 main categories; the patient data, HD data and laboratory results
Results: Data analysis revealed that the incidence of cardiovascular events is high and its prognosis is poor in patients undergoing maintenance HD. Reversible risk factors include hypertension [HTN] and possibly the amount of HD prescribed
ABSTRACT
The objective of this work was to determine the seroconversion rate andfactors affecting immune response after vaccination of Egyptian infants withrecombinant DNA hepatitis B vaccine, and to evaluate the persistence of antibodyresponse [anti-HBs] in the vaccines at one year after primary vaccination. Seroconversion was detected in 155 vaccinated infants, of whom 125 were goodrespondents and 30 infants were moderate responders and 11 infants werepoor or non- responders. Immune response was not influenced by gender, modeof feeding or nutritional status. All infants with primary good responseretained protective antibody titer, while only 40% of the moderate respondersretained protective antibody level