ABSTRACT
The aim of this study was to evaluate the effect of n butyl-2-cyanoacryl ate on bone healing. Thirty adult male guinea pigs with an average weight of 400-500 grams were used in this study Animals were divided into two groups [A and B] Group [A] included 21 animals, and Group [B] was a control group which included 9 animals. Each animal of both groups was subjected to a unilateral [left side] mandibular body surgically created [1] mm width bony defect, the inferior border of the mandible was left intact, the surgically created defects of Group [A] were filled with Bulyl-2-cyanoacrylate. While, the surgically created defects of Group [B] were left to heal spontaneously without any materials added. Clinical results and observations showed no infection or foreign body reaction in any of the animals either the control or the study group Histological results by the end of the second week the histoacryl group showed less granulation tissue and mild inflammation compared to the control sites At the end of the third week, the control showed more pronounced granulation tissue regression and decreased inflammation compared to the study sites, and by the end of the fourth week, both the control and study sites exhibited similar histology with absence of inflammation and granulation tissue. The application of cyanoacrylate tissue adhesive to bone defects shows absence of foreign body reactions, infection, and no disturbance of bone heating, with an anti-inflammatory effect, yet it should be used with caution to decrease the amount of the glue introduced inside the gap as a residue of the glue was seen histologically in the first two weeks after the application