ABSTRACT
Introduction: Uric acid (urate), an organic compound ofcarbon, nitrogen, oxygen and hydrogen has been thought to beprotective against ageing, oxidative stress and oxidative cellinjury owing to its oxidant property. Recent epidemiologicaland clinical evidences suggest that hyperuricaemia might be arisk factor for cardiovascular disease where enhanced oxidativestress plays an important pathophysiological role. The studyis taken up to determine serum uric acid levels in AcuteCoronary Syndromes (ACS) and to compare the incidence ofcomplications in hyperuricaemic and normouricaemic acutecoronary syndrome patients.Material and Methods: A prospective cohort study wasconducted in the Department of Medicine in collaborationwith Department of Biochemistry, RIMS, Imphal fromOctober 2014 to September 2016, among 73 normouricaemicACS patients and 73 hyperuricaemic ACS patients. Clinicaland anthropometric data were taken from each subject.Laboratory evaluation involves serum uric acid by enzymaticcolorimetric method.Results: The mean serum uric acid level in the studypopulation was 5.96 ± 1.88 mg/dl. Arrhythmias occurred in27.4% of hyperuricemic patients and 5.5% of normouricemicpatients. It is observed that 27 patients developed congestivecardiac failure (CCF), out of which 17 patients (22.3%)were hyperuricaemic and 10 patients (13.7%) werenormouricaemic. Pulmonary edema (PE) was observed in 35hyperuricaemic and 28 normouricaemic patients (47.9% and38.4% respectively).Conclusions: Complications of ACS such as arrhythmias,CCF and PE occurred more frequently in hyperuricaemicindividuals. Thus, it can be concluded that serum uric acidlevel can be considered a suitable marker for predicting ACSrelated future adverse events.
ABSTRACT
Introduction: Rheumatoid Arthritis is a chronic systemic inflammatory disorder that may affect many tissues and organs but principally affects the joints. Our study aims to access serum lipid profile as well as atherogenic index – Total cholesterol/HDL cholesterol, LDL cholesterol/HDL cholesterol among the RA patients and compare the results with that of control group and also to estimate Vitamin E levels in cases and compare it with controls. Methods: Fifty diagnosed cases of Rheumatoid Arthritis and thirty healthy age and sex matched individuals were included in this study. Serum triglycerides, HDL cholesterol, LDL cholesterol, VLDL cholesterol and Vitamin E were estimated in these groups. Results: Among cases the values of Vitamin E were significantly lower (0.25 ± 0.06 mg/dl ± SD) as compared to controls (1.12 ± 0.23 mg/dl ± SD). S. VLDL (30.09 ± 3.33 mg/dl ± SD) and S. LDL (220.96 ± 34.19 mg/dl ± SD) values were significantly higher among cases (18.57 ± 4.63 mg/dl ± SD, 36.2 ± 15.59 mg/dl ± SD respectively in controls). The value of S. HDL was found to be significantly lower (25.04 ± 6.27 mg/dl ± SD) in cases as compared to controls (58.83 ± 11.43 mg/dl ± SD). Among cases values of Total cholesterol/HDL cholesterol (11.78 ± 3.47) and LDL cholesterol/HDL cholesterol (9.48 ± 3.18) were also higher than controls (1.99 ± 0.42, 0.66 ± 0.37 respectively). Conclusion: These findings strongly confirmed that patients with RA have significantly lower values of vitamin E and HDL compared to controls while higher values of other parameters of lipid profile and higher atherogenic indices.
ABSTRACT
Aims: To evaluate the level of lipid peroxidation (by measuring malondialdehyde) and endogenous antioxidant enzyme (glutathione peroxidase) in acute myocardial infarction. Study Design: Cross sectional study. Place and Duration of Study: Department of Biochemistry in collaboration with Department of Medicine, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India between November 2010 to April 2012. Methodology: Fifty patients (32 male, 18 female) between the age group of 18-90 years suffering from acute myocardial infarction either attending emergency department, out patients department or admitted in intensive care coronary unit (ICCU) RIMS, within 6 hours from the complaint of chest pain were included in the study. Another thirty age and sex matched healthy individuals (18 male and 12 female) were taken as controls. Glutathione peroxidase (GPx) and malondialdehyde (MDA) levels were estimated by Beckman DU 640 spectrophotometer using commercially available kit. The data was analysed using SPSS version 16. Results: The plasma malondialdehyde mean level (4.02±0.72 μmol/L in males and 3.77±0.58 μmol/L in females) was significantly high in the AMI patients compared to the control group (1.34±0.22 μmol/L in males and 1.30±0.26 μmol/L in females) however the glutathione peroxidase mean level (23.3±4.2 u/gHb in males and 23.0±3.6 u/gHb in females) was significantly reduced in AMI patients than the controls group (29.68±1.4 u/gHb in males and 29.57±1.0 u/gHb in females). Conclusion: In conclusion AMI patients have increased oxidative stress and a compromised antioxidant defense system. Therefore, it is recommended that the management strategy for the patients of AMI should include specific antioxidant supplementation along with lowering of lipid peroxidation.