ABSTRACT
Background: Nausea vomiting of pregnancy [NVP] is a common problem .A severe form called hyperemesis gravidarum occurs in 0.3-2.3% of pregnancies, which can adversely affect the lifestyle. This study is conducted to improve the confidence of obstetricians for treatment of nausea and vomiting of pregnancy
Objective: To determine the efficacy of doxylamine succinate with pyridoxine combination in nausea and vomiting of early pregnancy
Methods: Study conducted at Dr. Ziauddin University and Hospitals Karachi, from 25-02-2011 to 25-07-2011. Study design was case series, during the period of study total number of OPD patients in gynaecology and obstetrics department Ziauddin hospital were 821, out of them 190 patients of 20 years to 39 years of age with 9+ 2 weeks gestation were enrolled and sample was taken by Consecutive sampling
Results: 182 [95.8%] patients reported improvement in symptoms i.e. positive efficacy, 7 patients [3.7%] reported no difference in nausea vomiting and only 1 patient i.e. 0.5% reported aggravation of her symptoms. Total PAQUE score before treatment was as high as 12.3526 with standard deviation of 2.12739, which reduced to 5.7211 with standard deviation 2.0908 after treatment of nausea vomiting with doxylamin succinate + pyridoxine combination. P value calculated for total PAQUE score before and after treatment is 0.000
Conclusion: This study concluded that for nausea and vomiting of pregnancy, doxylamine succinate is effective when given for moderate to severe symptoms. So it should be considered as 1st line of treatment for nausea and vomiting of pregnancy
ABSTRACT
Infertility is very stressful event and is proven to associate with depression, anxiety, sexual dysfunction loneliness, sadness and impaired couple's relationship
Objectives: To determine the frequency of depression in infertile females and to determine the various risk factors associated with infertility and depression
Study Design: Prospective cross sectional study
Setting: Department of Obstetrics and Gynecology of Ziauddin University Karachi
Period: January to June 2014
Methodology: Infertile women were interviewed and the diagnosis and severity of depression was assessed together with the effects of different predicators such as age, duration of infertility, employment educational and socioeconomical status using PHQ- 9 scale scoring
Results: This study showed that 199 [58%] of the infertile women suffered from depression. There was a statistically significant association with socio economical status while no significant association was detected with age of women, duration of infertility and educational status
Conclusion: We found a high prevalence of depression among infertile women. Depression was more among women belonging to higher socioeconomic class