ABSTRACT
Mucormycosis is the name for invasive fungal infection caused by mucorales. The disease is uncommon and produces serious and rapidly fatal infection in patients with serious pre-existing illness. The classical presentation of rhinocerebral mucormycosis is involvement of nasal mucosa with invasion of paranasal sinuses and orbit. We report a case of mucormycosis in an otherwise healthy female who had developed acute renal failure following gastroenteritis.
Subject(s)
Adult , Anti-Bacterial Agents/therapeutic use , Central Nervous System Infections/etiology , Fatal Outcome , Female , Gastroenteritis/complications , Humans , Immunocompetence , Acute Kidney Injury/complications , Mucormycosis/diagnosis , Nose/pathologySubject(s)
Adult , Cerebellar Ataxia/etiology , Herpes Zoster Ophthalmicus/complications , Humans , MaleABSTRACT
Salmonella species is the accepted organism causing osteomyelitis in sickle cell disease. Klebsiella pneumoniae is now emerging as a new etiological agent. We report a case of sickle cell osteomyelitis due to Klebsiella pneumoniae.
Subject(s)
Adult , Anemia, Sickle Cell/complications , Humans , Klebsiella Infections/microbiology , Klebsiella pneumoniae/isolation & purification , Macrophages/physiology , Male , Osteomyelitis/etiologyABSTRACT
Radionuclide ventriculography was performed on 10 normal subjects and 39 patients with sickle cell anemia (10 homozygous and 29 heterozygous sicklers) at rest and after exercise. Their left ventricular (LV) function was assessed in both these situations. The results were then compared within the subgroups. The reduction in ejection fraction (EF) response (47.5 +/- 7 at rest and 46.4 +/- 8 at exercise in homozygous patients, and 52.4 +/- 8 at rest and 54.3 +/- 8 at exercise in heterozygous patients) was significant in both the homozygous and the heterozygous groups but more so in the former group. The diastolic filling was also significantly impaired in the homozygous group (PER 2.64 +/- 0.74, PFR 2.13 +/- 0.42 and PFR/HR 0.014 +/- 0.001). The study statistically demonstrates, that LV filling patterns are altered in the sickle cell patients, even in the absence of clinical symptoms relating to LV dysfunction. This fact may prove to be a marker of sickle cell heart disease. Frequent and significant sickling is probably the cause of more pronounced LV functional abnormalities in homozygous sicklers.