ABSTRACT
Lymphoma is a general term for a group of cancers that originate in the lymphatic system. The lymphomas are divided into two major categories: Hodgkin lymphoma and all others lymphomas, called Non-Hodgkin lymphomas. is to study the peripheral blood immunophenotypic features of T- lymphomatous cells among patients with Non-Hodgkin Lymphoma [NHL] attending Menoufyia University Hospitals, compared to normal, by 2-color flow cytometry immunophenotyping. The ratios of the subsets of T-lymphocytes and NK cells in the peripheral blood were measured for 25 NHL patients receiving treatment and attending for follow up by the consultant of oncology department, Minoufiya university hospitals. They were compared with those of 15 healthy, agematched controls. The measurements were accomplished by flow-cytometry. The patients had significantly decreased ratios of CD4+, CD8+ T-cells and CD4/CD8. With non-significant increased ratio of CD56+ [NK-T cells] comparing to controls. The subsets of T-Lymphocytes [T-helper and T-Cytotoxic] are suppressed in patients of NHL who receiving treatments than in controls. Neither presence of NK-T cells nor their absence helps in identifying the NHL disease