The anti-hyperglycemic effect of fructus lycii extraction on straptozocine-induced glucose intolerance mice and diabetic mice

Background: Continuation of previous study of screening traditional medicinal plants with anti-diabetic effect, the hypoglycemic effect of glue extracted from Fructus Lycii which was named HPD was study. Objective: to investigate the hypoglycemic effect of HPD on diabetic mice caused by different doses of streptozocine. Subjects and methods: causing diabetes by streptozocine at difference doses was used to collect glucose intolerance mice, mild diabetic mice and severe diabetic mice. The effect of HPD p.o. at several doses was evaluated after 3 days of use. Results: By oral allocation with the dose of 500 and 1.000mg/kg body-weight for 3 days, HPD inhibited increasing blood glucose in streptozocine-induced glucose intolerance mice (intraperitoneal STZ 100 mg/kg). HPD 1000 mg/kg body weight had the potent hypoglycemic effect on streptozocine-induced diabetic mice, reverse the blood glucose self control ability of mild streptozicine-induced diabetic mice (STZ 120 mg/kg), meanwhile can not stop a hyperglycemic effect of high dose of STZ (STZ 180 mg/kg). Conclusion: HPD has the potent anti-hyperglycemic effect on streptozocine -induced diabetic rats. Anti-hyperglycemic of HPD is indirect under present of insulin\r\n', u'\r\n', u'\r\n', u'

Screening study on the hypoglycemic effect of four traditional herbs

In this study, the extracts of four traditional herbs of ViÖt Nam (Hydrangea macrophylla, Eucommia ulmoides Olive, Scrophularia burianna Mig, Morinda ciuifolia L.) have been assessed for the hypoglycemic effect on normal mice. These extracts were administered by intraperitoneal or oral routes with dose of 200 - 300mg/kg, and 1000 - 1500mg/kg respectively. No evident hypoglycemic effect was showed with all extracts of these herbs