Trends in prediabetes and diabetes prevalence and associated risk factors in Vietnamese adults / 한국역학회지

OBJECTIVES@#The prevalence of diabetes mellitus is rapidly increasing in Vietnam, particularly among adults aged over 45 years. This study estimated trends in diabetes and prediabetes prevalence and determined risk factors in Vietnamese adults (over 45 years). @*METHODS@#A cross-sectional study was conducted based on data from an annual diabetes screening program among people aged 45-69 years in an urban city in central Vietnam (Da Nang). Joinpoint regression analyses were performed to calculate the annual percentage change and ptrend-values. Multinomial logistic regression analysis was used to determine risk factors. @*RESULTS@#In total, 3,765 men and 9,149 women were included in this analysis. The age-adjusted prevalence of diabetes and prediabetes in 2017 was 11.4% and 52.9%, respectively. The prevalence of diabetes was higher in men (15.1%) than in women (10.3%), but that of prediabetes was similar in both genders (53.4% vs. 52.8%). The prevalence of prediabetes significantly increased during the study period, whereas no upward or downward trend for diabetes was observed. The prevalence of obesity, abdominal obesity, hypertension, and dyslipidemia showed no obvious trend. Obesity, a high waist-to-hip ratio, hypertension, more severe abdominal obesity, and dyslipidemia were significantly associated with a higher risk of diabetes and prediabetes. @*CONCLUSIONS@#Diabetes and prediabetes were more prevalent among people aged over 45 years than in the general population. Da Nang has experienced a marked increase in the prevalence of prediabetes. These findings have significant implications regarding the need for nationwide public health interventions and management aiming at diabetes prevention and control.

Trends in prediabetes and diabetes prevalence and associated risk factors in Vietnamese adults / 한국역학회지

OBJECTIVES@#The prevalence of diabetes mellitus is rapidly increasing in Vietnam, particularly among adults aged over 45 years. This study estimated trends in diabetes and prediabetes prevalence and determined risk factors in Vietnamese adults (over 45 years). @*METHODS@#A cross-sectional study was conducted based on data from an annual diabetes screening program among people aged 45-69 years in an urban city in central Vietnam (Da Nang). Joinpoint regression analyses were performed to calculate the annual percentage change and ptrend-values. Multinomial logistic regression analysis was used to determine risk factors. @*RESULTS@#In total, 3,765 men and 9,149 women were included in this analysis. The age-adjusted prevalence of diabetes and prediabetes in 2017 was 11.4% and 52.9%, respectively. The prevalence of diabetes was higher in men (15.1%) than in women (10.3%), but that of prediabetes was similar in both genders (53.4% vs. 52.8%). The prevalence of prediabetes significantly increased during the study period, whereas no upward or downward trend for diabetes was observed. The prevalence of obesity, abdominal obesity, hypertension, and dyslipidemia showed no obvious trend. Obesity, a high waist-to-hip ratio, hypertension, more severe abdominal obesity, and dyslipidemia were significantly associated with a higher risk of diabetes and prediabetes. @*CONCLUSIONS@#Diabetes and prediabetes were more prevalent among people aged over 45 years than in the general population. Da Nang has experienced a marked increase in the prevalence of prediabetes. These findings have significant implications regarding the need for nationwide public health interventions and management aiming at diabetes prevention and control.

Safety of Balloon Kyphoplasty in the Treatment of Thoracic Osteoporotic Vertebral Compression Fractures in Vietnamese Patients

Background@#The evidence for the efficacy and safety of balloon kyphoplasty (BKP) in treating the Vietnamese patients is sparse. There is no convincing evidence regarding BKP’s efficacy in Vietnamese patients, especially in the patients with thoracic osteoporotic vertebral compression fractures (VCFs). This article aims to evaluate the outcomes of restoring the body height of the compressed thoracic vertebrae in patients undergoing BKP. @*Methods@#We prospectively enrolled 65 consecutive patients with thoracic VCFs (73 vertebrae) due to osteoporosis who were treated with BKP between June 2018 and May 2019. @*Results@#A trocar was inserted through the pedicle in 84.9% (62/73) and beside the pedicle in 15.1% (11/73). The mean amount of mixed cement injected was 4.1 ± 1.1 mL (range, 1.5–7 mL). Cement leakage was radiographically confirmed in 30.8% of 65 patients. Among patients with complications caused by cement extravasation, the leakage was through the anterior margin of the vertebrae in 15.4%, through the vertebral disc in 12.3%, and through the posterior margin of the vertebrae in 3.1%. In the last 3.1% of patients, there was no clinically notable lesions of the nerve roots or spinal cord. The mean visual analog scale score decreased significantly from 7.3 ± 1.1 preoperatively to 3.3 ± 0.6 at 24 hours after surgery, and then to 1.2 ± 1.1 at 3 months after surgery (p < 0.01). The mean reduction in Cobb angle measured on standing radiographs after treatment was 3.7°, showing statistical significance (p < 0.01). @*Conclusions@#BKP is a minimally invasive treatment effective for immediate pain relief, early motor rehabilitation, and humpback correction. The present study provided convincing evidence to support the use of BKP by spine surgeons and clinical specialists in treating osteoporotic thoracic VCFs in Vietnamese patients.

Downregulation of kinesin spindle protein inhibits proliferation,induces apoptosis and increases chemosensitivity in hepatocellular carcinoma cells

Kinesin spindle protein [KSP] plays a critical role in mitosis. Inhibition of KSP function leads to cell cycle arrest at mitosis and ultimately to cell death. The aim of this study was to suppress KSP expression by specific small-interfering RNA [siRNA] in Hep3B cells and evaluate its anti-tumor activity.Three siRNA targeting KSP [KSP-siRNA 1-3] and one mismatched-siRNA [Cont-siRNA] were transfected into cells. Subsequently KSP mRNA and protein levels, cell proliferation, and apoptosis were examined in both Hep3B cells and THLE-3 cells. In addition, the chemosensitivity of KSP-siRNA-treated Hep3B cells with doxorubicin was also investigated using cell proliferation and clonogenic survival assays.The expression of endogenous KSP at both mRNA and protein levels in Hep3B cells was higher than in THLE-3 cells. In Hep3B cells, KSP-siRNA 2 showed a further downregulation of KSP as compared to KSP-siRNA 1 or KSP-siRNA 3. It also exhibited greater suppression of cell proliferation and induction of apoptosis than KSP-siRNA 1 or KSP-siRNA 3. This could be explained by the significant downregulation of cyclin D1, Bcl-2, and survivin. In contrast, KSP-siRNAs had no or lower effects on KSP expression, cell proliferation and apoptosis in THLE-3 cells. We also noticed that KSP-siRNA transfection could increase chemosensitivity to doxorubicin in Hep3B cells, even at low doses compared to control. Reducing the expression level of KSP, combined with drug treatment, yields promising results for eradicating hepatocellular carcinoma [HCC] cells in vitro. This study opens a new direction for liver cancer treatment.

Intestinal parasitic infections in schoolchildren in a suburban area of Hanoi, Vietnam.

An epidemiological study on intestinal parasitic infections among schoolchildren in a suburban area of Hanoi, Vietnam, was conducted. Of the 217 schoolchildren involved in this study, 166 (76%) were positive for at least one of nine species of parasite (six helminths and three protozoa). Among the helminth parasites, Trichuris trichiura (67%) was detected the most frequently followed by Ascaris lumbricoides (34%) and hookworm (3%). In the case of protozoan parasites, Entamoeba coli (8%) was the most frequently detected followed by E. histolytica (2%). No Cryptosporidium parvum or Cyclospora sp were found. A questionnaire survey revealed that there was no positive relationship between parasite infection and the children's school records, educational background or parental income, which have been known to play a role.

Current status of soil-transmitted helminths in Vietnam.

This paper provides a review of surveys on soil-transmitted helminths that were done in Vietnam between 1990 and 2001. Prevalence estimates could be obtained for 29 of the 61 provinces. Extrapolating from this, it is estimated that 33.9 million people in Vietnam are infected with Ascaris (prevalence 44.4%), 17.6 million with Trichuris (prevalence 23.1%), and 21.8 million with hookworm (prevalence 28.6%). Prevalence of Ascaris and Trichuris showed a declining trend from the north to the south of the country. This is probably related to differences in climatic conditions. Hookworm prevalence is more evenly distributed throughout the country, but is concentrated in peri-urban and rural agricultural areas. Vegetable cultivation in which nightsoil is used as fertilizer is a risk factor for hookworm infection, especially among adult women. Helminth control programs should be targeted at school-age children in the northern provinces. Specific interventions are needed throughout the country for women of agricultural communities that are at risk for hookworm infection. There is clearly a need for more detailed analysis of risk factors to quantify the relative contribution of climatic, environmental, and human behavioral factors in the transmission of intestinal nematode infections in Vietnam.

Mother's management for children under five years who suffered from the disease

A study on mothers with children under five years who suffered the disease in 2 villages of Viªn and §«ng at Cæ NhuÕ commune, Hµ Néi has shown that rate of children under five years suffered from the disease was 12.80%. Rate of bronchitis, pneumonia among children under 5 years were highest, followed by pharyngitis (25.6%), amygdalitis (9.6%). The rate of mother who transferred their children to the communal health station was 61.60%, to the private clinics (24.40%) and to hospital (6.4%).

The bursar for the consultation and treatment in the hosehold in the publicity

A cross sectional survey and dirrect interview of 3,883 households in Co Nhue commune, Tu Liem district in which rich households: 1,359 (35%); poor househould: 39 (1.004%), avarage income/month: 250,000 VND/ capital/month were implemented during 1-4/1998. The results have shown that the average bursar/capita/round in the hospital was 195,700 VND; The highest bursar/ child with ages of 5/ round was 69,800 VND and lowest bursar capita with ages of 15-60/round was 37,172. The level of this expenditure was higher 15 times than this in the publicity. Therefore, 75/138 people who think that the bursar of consultation and treatment in hospital was excessive expensive.

Needs of home health care of people in suburb of Hµ Néi

A Sociological survey of 1500 households in 30 communes in Hanoi' s suburbs shows that 1337/1500 households (89.13%) want to be provided with home health care service 25.42% consider this as a measure to improve health - care quality in the community

study on the needs of health care and use of health services

1000 households with 6,125 persons were randomly selected from 2,773 households with 16,731 persons in Co Nhue commune, Tu Liem district, Hanoi participated to a study on the determination of needs of healthcare and use of health service. In which the direct subjects were householders and mothers with children under 6 years. The results have found that there was no difference of morbididy rate between men and women. Children under 5 years accounted for highest morbidity rate (22.6%). There was high needs of healthcare for children in the community, especially the respiratory tract infection. The children came to the communal health station and convenient health care facilities accounted for 35.06% because of the good profession and attitude.

Situation of enviromental sanitation in ThuaThien-Hue province

Cross-sectional surveys were carried out in ThuaThien-Hue province successively in 1993, 1997 and 2000. Percentage of households using tap water in Hue city: 1993: 71.6%; 1998: 76.9%; 2000: 87.5%. However the percentage of households having clean latrines was still low: 1993: 49.3%; 1998: 63.3%; 2000: 52.9%. This was due to the damages caused by the severe flood, which occurred in November - December 1999.

Primary investigation of drug use in community

1,000 households (25.75%) were selected randomly from 3,883 households, included 6,125 persons in Co Nhue Commune, Tu Liem district, Ha Noi City from January to March, 1998. It is found that the medications were mainly required for common cold, fever, cough and fatigue. The drug consumers were involved in every age groups, in which the drug consumption was higher in under-5-year children due to the rate of illness was higher in this age group. The drugs have been used unsafe and inappropriately. Antibiotic overuse was 68.04%. 10.28% of illness persons have used corticoids, while a few persons used traditional medication, pain killers and antipyretics for illness.