Cardiovascular autonomic nervous system and its relation with duration of disease, body mass index in patients with diabetes mellitus type 2

Cardiovascular autonomic dysfunction is an early and common complications in type 2 diabetes. Objectives: (1) to determine the parameters of cardiovascular autonomic nervous system by assess the variability of heart rate, blood pressure and (2) to describe its relation to duration of disease, body mass index in 91 patients with diabetes type 2. Methods: We assessed cardiovascular autonomic nervous system by Ewing's maneuvers in comparison with normal subjects. Results: heart rate has little change, indicate that activity of parasympathetic nervous system is reduced. An increased position hypotension was found in the patients. Vasocostriction is rudeced. Conclusions: The variability of heart rate and blood pressure in patients with diabetes mellitus were significantly correlated with the duration of disease and did not correlate with the body mass index.

Study on serum iron and ferritin concentration in patients with chronic renal failure

Study on 124 persons divided into 2 groups: the control group included 40 healthy persons (20 male, 20 female) and the case group included 84 patients with chronic renal failure at different stages. The mean age of 2 groups was similar. The diagnosis of chronic renal failure mostly depended on glomerular filtration rate <60 ml/minute and that lasted ≥6 months. Results: serum iron and ferritin concentrations of male and female in control group weren’t different significantly. 39.3% of patients decreased serum iron concentration, 60.7% of patients decreased serum similar to those of the control group. Compare 2 indexes of serum iron and serum ferritin by test X2 (X2=15.29; p<0.001), results showed that ferritin concentration decreased much more than serum iron. The rate of patients with low ferritin concentration was high (55.95%). Serum iron and ferritin concentrations of patients with chronic renal failure at stage IIIa, IIIb, IV decreased statistically in comparison with control group.

Evaluation of therapeutic effect in patients with diabetes type 2 based on glucose level and HbA1C

The study investigated therapeutic effect in 98 patients with diabetes type 2 (59 males, 39 females, 34 - 80 years old) who have diagnosis in first time or are monitored at the National Institute of Endocrine. Results showed that first test of the patients who have recent diagnosis or following-up examination showed a higher levels of glucose and HbA1C than that in normal people. The average levels of glucose and HbA1C in following visits were reduced but still higher than that in normal people

Evaluating risk factors for developing atherosclerosis on patients with nephrotic syndrome basing on blood lipid indicator

The survey on serum lipid level and atherosclerosis risk on 70 patients with chronic nephritis and nephrotic syndrome (51 male, 19 female, 18-52 years old) showed that average value of cholesterol level, triglycerides, LDL-C and Apo B levels increased, HDL-C, Apo-A1 decreased in comparison with those in normal people. Absolute rate of cases with increased cholesterol, triglycerides and LDL-C at high level were 100%, 97% and 62.86%, respectively. Atherosclerosis risks based on blood lipid indicators were rather high, of which 77.14% for CT/HDL-C; 47.14% for LDL-C/HDL-C and 72.86% for Apo-B/Apo-A1

Study on the changes of blood - lipid ratio in primary nephrotic syndrom before and after treatment

Study on the changes of blood - lipid ratio in primary nephrotic syndrom under effect of general treatment. Objects included 43 patients (34 men and 9 women) at the age from 18 to 44. The result showed that: In patients with nepherotic sydrome, through treatment increased total cholesterol, triglyceride, LDL-cholesterol, Apolipoprotein A1 and Apolipoprotein B, descreased HDL cholesterol.After the treatment without use lipid lowering actions of drugs, the result show that reduction of total and LDL-cholesterol, triglyceride, Apolipoprotein A1 and Apolipoprotein B, increased of HDL cholesterol.

Studying condition of serum glucose tolerance in hypertensive patients

The study carried out glucose tolerance test in 43 healthy people with normotensive (control group) and 131 patients with hypertension in various levels and periods (disease group) who have blood fasting glucose less than 7mmol/l. The results showed that: the percentage of patients with diabetes or glucose tolerance impairmentand the mean value of serum glucose in second hour in disease group were higher significantly than that of control group. The rate of glucose tolerance disorder in hypertensive patients was higher by 3.18 times, in which the rate of glucose tolerance impairment was higher by 3.82 times. The rate of diabetes was higher by 2.54 times than control group. Hypertension with overweight had higher risk of reducing glucose tolerance or getting diabetes

Study on HBA1C level in type 2 diabetes patient

Study on 98 type 2 diabete patients have been ill first time or being treat periodic. The result: HbA1C was significant higher than normal subjects at all test times. Means HbA1C values gradually decreased at test times of Co, C3, C6, C9, within at C3 and C6, this value is equivalent. This proved that controling plasma glucose of diabetes was improved better. However, this haven’t satisfied yet with treatment goal. The correlation between HbA1C and plasma glucose is closely direct proportion, between HbA1C and plasma insulin is moderately inverse proportion

Study on heart rate varying and blood pressure related to cardiovascular neuroself-controll in type 2 diabetes

Study on 91 type 2 diebetes patients without hypertention by 4 tests of Ewing (40 men and 51 women, mean old of 2 group is equivalent). Control group include 40 healthy persons (20 men and 20 women). The result: in 2 tests of heart autonomic neurophathy function of diebetes patient, alteration of heart rhythm occur lower than control group. When altering suddenly position, diastolic blood pressure decreased much than controls. Variation of blood pressure in dynamometer handgrip test of patient decreased significantly compared to controls, heart frequency increased higher than controls. Heart autonomic neurophathy dysfunction occur at 62,6% cases in deep breathing test and at 70,3% cases in fast standing test, all of them are higher than controls. Heart autonomic neurophathy dysfunction occur at 38,5% cases of systolic hypotention and 70,3% of diastolic hypotention to standing

Metabolic syndrome in hypertensive patients

With a control group of 43 health persons a study was performed on 131 hypertensive patients using the test of glucose tolerance. The average similar in 2 groups. In both 2 groups, an incidence of 36,78% of metabolic syndrome was concluded, among them 41,22% were in hypertensive group and 23,26% in control. The factors occurred with high frequency were diabetes, poor tolerance with glucose, BMI ≥ 23, high triglyceride levels ans low HDL- C levels subsequently