Comparación del consumo de drogas en una población escolar de género masculino utilizando la metodología de pares y el cuestionario auto registrado estándar / Drug consumption in the masculine school population using the peer methodology and the standard self assessment questionnaire

El objetivo es comparar el consumo de drogas a través de dos metodologías, la metodología de pares (MP) y la metodología del cuestionario auto registrado (CAR). La población está compuesta por escolares de género masculino, que cursan entre 8° básico y 4° medio. La muestra alcanzó a 301 escolares. Los resultados obtenidos son, una tendencia a mayor consumo general con la MP que con el CAR; igualmente, en el último mes el consumo muestra una tendencia al aumento con la MP en comparación con el CAR. En ambos períodos no hubo significación estadística. Por otro lado, el consumo de drogas ilícitas en los últimos 12 meses, fue el doble con la MP. En cuanto al consumo de los últimos 30 días, también se duplica al indagar con la MP. La declaración del consumo de drogas ilícitas es significativamente mayor con la MP que con el CAR, en ambos períodos estudiados. El consumo de marihuana, en ambos períodos, es el de mayor consumo entre las drogas ilícitas. Todas las diferencias alcanzaron significación y por lo tanto, la hipótesis que indica utilizando la MP se obtiene mayor declaración del consumo de drogas ilícitas se ratifica.

The objective of this study is to compare the declared licit and illicit drug consumption, between paired methodology (MP) and self assessed questionnaire (CAR). We suggest that understatement of illicit drug use will be minimized with the use of peer methodology, and that licit drug understatement will not be affected using peer methodology. The population of this study is composed by male school students ranging between middle and high School. The sample reached to 301 students. The results obtained regarding illicit drug consumption in the year, tend to be higher using MP compared with the CAR. Similarly, last month consumption reached a higher prevalence using MP than using CAR. There are no significant differences in both samples, during both periods. Nevertheless, in the last 12 months, illicit drug consumption doubled the CAR report in comparison to MP. Regarding drug consumption in the last 30 days, the results also showed that CAR underestimated half of the rate stated using MP. Illicit drug consumption is significantly higher using MP, than CAR, in both periods that were studied. Illicit consumption rates of in the past year and in the last month are significantly higher using MP, particularly with Marihuana. There are no statistical differences in the same periods, regarding licit drug consumption rate, as alcohol and tobacco.

Humoral immune responses against Plasmodium vivax MSP1 in humans living in a malaria endemic area in Flores, Indonesia.

The aim of this study was to evaluate the relationship among age, parasitemia status, spleen size, hematocrit, and antibody levels to Plasmodium vivax merozoite surface protein 1 (MSP1) in individuals chronically exposed to P. vivax. Subjects were recruited from the population of three adjacent villages on the Island of Flores in Indonesia where malaria transmission is hyperendemic and tropical splenomegaly syndrome is highly prevalent. Subjects were evaluated for spleen size, hematocrit, presence of parasitemia, and presence of antibodies to a recombinant peptide consisting of 90 amino acids from the carboxy terminus of MSP1. Fifty-seven percent of 2-4 year olds, 45% of 5-9 years old, and 7% of > or = 15 years old were parasitemic; 99% of the > or = 15 years old had splenomegaly, and 31% of them had Hackett 4 or 5 spleens. The frequency of antibody positivity to MSP1 antigen in ELISA increased with age reaching a maximum of 89% in > or = 20 years old. The frequency of antibody positivity to MSPI also increased with spleen size, and with a decline in the prevalence of parasitemia.

DNA vaccines for malaria: the past, the present, & the future.

The first clinical trial of a DNA vaccine designed to protect against malaria has just commenced. This vaccine has been designed to induce protective CD8+ T cell responses against Plasmodium falciparum infected hepatocytes. Herein, we review the rationale behind the development of vaccines that induce protective CD8+ T cells, the strategy for the development of a DNA vaccine designed to protect against falciparum malaria, and the experimental data in rodent models and nonhuman primates which has provided the foundation for trials of DNA vaccines against P. falciparum malaria in humans.

Eficacia do moxalactam no tratamento de meningites purulentas causadas por Haemophilus infuenzae e Neisseria meningitidis. / Efficacy of moxalactam in the treatment of purulent meningitis caused by Haemophilus influenzae and Neisseria meningitidis

Foi avaliada a eficacia do moxalactam no tratamento de meningites em criancas, causadas por H. influenzae (27 casos) e N.meningitidis (6 casos). Dos 33 doentes tratados na dose de 100mg/Kg de peso (dose de ataque) e 50mg de 12/12 horas por via venosa, 32 curaram-se. A tolerancia ao produto foi muito boa, havendo alteracoes transitorias de transaminases e fosfatase alcalina; em um caso, houve hematoma posapendectomia, provavelmente relacionado ao uso deste antibiotico. Os niveis sericos e liquoricos do produto foram elevados; as concentracoes no liquor excederam de muito a concentracao bactericida minima dos germes infectantes. O moxalactam se mostrou seguro e eficaz como terapia primaria da meningite causada por H. influenzae e N.meningitidis em criancas

Choque anafilactico durante la anestesia / Anaphylactic shock during anesthesia

Se describe un caso de reaccion anafilactica ocurrido durante la intervencion quirurgica por quistes hidatidicos multiples, en pulmon, que determino su posterior muerte. Se discute las caracteristicas del choque anafilactico bajo anestesia y el tratamiento a instituir