ABSTRACT
Acute Radiation- induced Skin reaction [ARISR] is a common side effect in the majority of patients receiving radiotherapy. ARISR is often characterized by swelling, redness, pigmentation, dry and moist desquamation, edema, ulceration, bleeding and necrosis of the Skin. This study was carried out to evaluate prevalence and severity of ARISR in patients with head and neck cancer undergoing radiotherapy and determining skin dose-response relationship. From December 2014 to September 2015, we evaluated 88 patients with head and neck cancer. The acute skin toxicity was scored based on RTOG toxicity criteria. Analysis of data using statistical software SPSS [version20] and ANOVA or chi- square test was done, with P
ABSTRACT
The liver is an organ at risk [OAR] in radiotherapy of thoracic and abdominal tumors such as gastric, distal esophagus, lower lung and breast, bile duct, pancreas and whole abdomen. In this study the alteration in liver functional tests [LFT] of these patients during radiotherapy was investigated. To that end, the level of serum aspartate aminotransferase [AST], alanine aminotransferase [ALT], alkaline phosphatase [ALP], direct and total bilirubin were checked out at different times [before radiotherapy and every 2 weeks after the start of radiotherapy and followed up to 2 months after the end of treatment]. The results showed that LFT level increased during radiotherapy while they gradually decreased after treatment. Our results showed that the LFT serum is a very sensitive and useful biomarker for evaluation of the radiotherapy effects