ABSTRACT
It is well known fact that diabetics are prone to develop infections and have increased mortality and morbidity than non-diabetics. However, the effect of diabetes mellitus on the risk of pneumonia remains uncertain. We wanted to study the aetiology, clinical features, and the outcome of pneumonia in diabetic patients. METHODSA comparative observational study was conducted in a tertiary care hospital, southern India which included 50 diabetic patients with pneumonia and 50 non-diabetic patients with pneumonia. Clinical characteristics, x-ray findings, aetiological agents, and outcome of diabetic patients were analysed and compared with data from the control group. RESULTSDiabetic patients with pneumonia were more unwell at the time of admission in the form of high PSI (Pneumonia Severity Index) score (p = 0.004**), intensive care admissions and prolonged hospital stay (p = < 0.001**). Diabetic patients were significantly associated with multilobar involvement (p = 0.045*). There was no significant difference in age, gender, coexisting underlying disease and complications. In patients with diabetes mellitus, mortality was associated with multilobar infiltrate, increased PSI score (p = 0.078*) at admission. CONCLUSIONSThese is a significant difference between pneumonia in diabetics compared with non-diabetics. Diabetic patients had presented with higher PSI score, required more ICU admissions and had prolonged hospitalization. Diabetes is also associated with bad prognosis and high mortality.
ABSTRACT
The treatment of chronic inflammatory skin conditions are not satisfactory. There is a need for better antiflammatory drugs for these conditions. This study was done to compare the efficacy of biopolymer based formulations of clobetasol propionate and clobetasol butyrate with commercially available Preparations of clobetasol in animal models of superficial skin inflammation in rats. The croton oil ear edema in rats was the chronic inflammatory model used in this study. In this model, the animals treated with clobetasol propionate and clobetasol butyrate with biopolymer showed a significant decrease in inflammation as compared to commercially available preparations of clobetasol(Tenovate and Eumosone).
ABSTRACT
Topical antibiotic like Calcium mupirocin and its combination with steroid Fluticasone are commonly used to treat burn wounds. But whether they influence healing of wounds is not known. Aim: To compare the effect of Calcium mupirocin and Fluticasone of Apex Laboratories Chennai, on experimentally induced burn wound healing in Wistar rats and compare with available market preparation Mupirocin and Fluticasone -mupirocin combination. Method: Partial thickness burn wound was inflicted, on Wistar rats under ketamine (50mg/kg/i.p) by pouring hot molten wax at 80◦ C into a metal cylinder of 300 mm2 circular opening placed on shaven back of the rat. Animals with partial thickness burn wounds were divided into 7 groups (n=10). Group I did not receive any drug and served as control group. Group II, III, IV, V, VI, and VII received Calcium mupirocin A, Calcium mupirocin B, Mupirocin, Fluticasone+Calcium mupirocin A combination. Fluticasone +Calcium mupirocin B combination and Fluticasone -mupirocin combination creams respectively, twice a day for 21 days or till complete healing whichever was earlier. Results: Calcium mupirocin significantly decreased the duration of epithelialization and increased % of wound contraction in comparison to the control group. This was confirmed by Histopathology studies. Conclusion: Calcium mupirocin of apex possess significant wound healing properties.