Expression of MYB protein in adenoid cystic carcinoma of the salivary gland / 临床与实验病理学杂志

Purpose To investigate the role of MYB in adenoid cystic carcinoma (ACC) of different origins and grades.Methods A total of 103 specimens of salivary gland tumors with complete pathologic data were collected from the Department of Pathology, Affiliated Hospital of Inner Mongolia Medical University. 64 cases of ACC of the salivary gland, which included 19 cases of grade I, 27 cases of grade Ⅱ, and 18 cases of grade Ⅲ were selected as experimental group. 7 cases of exrras-alivary ACC and 32 cases of non-ACC benign and malignant tumor of salivary gland were served as control group. The MYB protein expression was detected by MYB immunohistochemical En Vision two-step staining for both experimental and control group. Results The positive expression rates of MYB in 64 cases of salivary ACC and 7 cases of extrasalivary ACC were 54.69％ (35/64) and 57.14％ (4/7), respectively, with no statistically significant difference (P> 0.05). The positive expression rates of MYB in 64 cases of salivary ACC and 32 cases of non-ACC salivary benign and malignant tumors were 54.69％ (35/64) and 6.25％ (2/32), respectively, which showed statistically significant difference (P < 0.05). The positive expression rates of MYB were 68.42％ (13/19), 66.67％ (18/27) and 14.29％ (4/18) in 64 cases of salivary ACC Ⅰ, Ⅱ and Ⅲ, respectively, and the difference was significant (P <0.05). The difference between grade Ⅰ and Ⅱ was not statistically significant (P> 0.016 7), while compared with grade Ⅲ, there was a statistical increase of positive expression rate of MYB in both grade Ⅰ and Ⅱ (P < 0.016 7). Conclusion MYB is highly expressed in grade I and Ⅱ of the salivary ACC and low expressed in grade Ⅲ. It is speculated that there may be other fusion gene mutation in salivary ACC grade Ⅲ. MYB is lowly expressed in non-ACC benign and malignant tumors of salivary gland, suggesting that MYB protein expression has a certain diagnostic value for the diagnosis of salivary ACC.

Effect of intervertebral finite fenestration on lubar intervertebral disc protrusion complicated with spinal stenosis / 新乡医学院学报

Objective To investigate the effect of intervertebral finite fenestration on lubar intervertebral disc protrusion (LIDP) complicated with spinal stenosis.Methods Eighty patients with LIDP complicated with spinal stenosis were selected from May 2014 to May 2016 in the 159th Hospital of the Chinese People's Liberation Army.The patients were divided into observation group and control group according to the treatment method,40 cases in each group.The patients in the observation group were treated with intervertebral finite fenestration,lateral recess and nerve root canal decompression.The patients in the control group were treated with total laminectomy,lateral recess and nerve root canal decompression.The lumbar pain of patients was evaluated by the visual analogue scale (VAS),and the lumbar function was evaluated by using Japanese Orthopaedic Association(JOA) scoring system in the two groups before and after operation.The postoperative complications were observed in the two groups.Results There was no significant difference in VAS score of lumbar pain between the two groups before operation (t =1.638,P ＜ 0.05).The VAS score of lumbar pain after operation was significantly lower than that before operation in the two groups(t =3.182,4.303,P ＜ 0.05).The VAS score of lumbar pain in the observation group was significantly lower than that in the control group after operation(t =2.776,P ＜ 0.05).There was no significant difference in JOA score of lumbar function between the two groups before operation(t =5.170,P ＜ 0.05).The JOA score after operation was significantly higher than that before operation in the two groups (t =28.841,45.070;P ＜ 0.05).The JOA score of the lumbar function in the observation group was significantly higher than that in the control group after operation(t =52.952,P ＜ 0.05).The total effective rate in the control group and the observation group was 62.5 ％ (25/40) and 92.5 ％ (37/40),respectively;the total effective rate in the observation group was significantly higher than that in the control group(x2 =12.381,P ＜0.05).The incidence of postoperative complications in the control group and observation group was 25.0％ (10/40) and 10.0％ (4/40),respectively;the incidence of postoperative complications in the observation group was significantly lower than that in the control group(x2 =11.140,P ＜ 0.05).Conclusion Intervertebral finite fenestration can effectively reduce lumbar pain,improve the lumbar function of patients with LIDP complicated with spinal stenosis;and it has fewer postoperative complications.

Study on the status and related socio-psychological factors of maternal depression among high-risk pregnancy women in Harbin city / 中华预防医学杂志

<p><b>OBJECTIVE</b>This study aimed to investigate the depression status among high-risk pregnancy women, and to analyze its relevant social and psychological factors.</p><p><b>METHODS</b>A total of 42 high-risk pregnancy women and 40 normal pregnancy women in a teaching hospital in Harbin city were followed up at time points of 32 - 36 weeks pregnancy, one week before labor, one week postpartum, and six weeks postpartum, respectively. During follow-up, the basic situation, social psychosocial factors of pregnancy women were collected and the depression of pregnancy women was measured by self-designed questionnaire and self-rating depression scale. The Edinburgh Postnatal Depression Scale (EPDS) was applied at timepoint of one week postpartum. Single factor analysis and the unconditional multivariate logistic regression were applied for analyzing the on the related social-psychosocial factors among high-risk pregnancy women.</p><p><b>RESULTS</b>The age of high-risk pregnancy women was (31.0±5.6), and the age of normal pregnancy women was (30.5±3.8) (t=0.169, P>0.05). The results showed that the depression rate in high-risk pregnancy women was 45.2% (19/42), which was 25.0% (10/40) in normal pregnancy women, the difference was significant (χ2=3.671, P=0.045). The depression rates at different time points were 30.9% (13/42), 42.9% (18/42), 23.8% (10/42), 26.2% (11/42) in high-risk pregnancy women respectively, and 25.0% (10/40), 15.0% (6/40), 20.0% (8/40), 17.5% (7/40) in the control group respectively, the difference of the depression rates among groups at one week before labor was significant (χ2=7.680, P<0.01), the difference among groups at 32-36 weeks pregnancy (χ2=0.133, P=0.80), at one week postpartum (χ2=0.174, P=0.79) and at six weeks postpartum (χ2=0.903, P=0.43) were not significant. At one week postpartum and six weeks postpartum periods, the EPDS depression rate were 12.5% (4/32), 30.4% (7/23) in case group respectively, 8.3% (3/36), 22.9% (8/35) in control group respectively, the difference were not significant (χ2=0.319, 0.416, P=0.573, 0.519). There were significantly associations between the depression mood of one week before labor and the depressive symptoms of six weeks postpartum in both groups (r=0.824, 0.677, both P values were <0.05). The risk factors for maternal depression among high-risk pregnancy women were not ready for production (OR=2.73, P<0.01) and fearing of childbirth safety (OR=2.89, P<0.01).</p><p><b>CONCLUSION</b>The depression date of high-risk pregnancy was high, especially at the time point one week before labor. Risk factors of maternal depression among high-risk pregnancy were "not ready for production" and "fear of childbirth safety".</p>

Dynamic study of correspondence of prescription and syndrome system: a system with combination of disease and syndrome, correspondence of prescription and syndrome / 中国中西医结合杂志

By analyzing the present situation and existing problems in the material bases of syndrome and Chinese materia medica, we think that either syndrome or prescription is a complex whole system. Studies of the material bases of syndrome and prescription should be established on the combination of disease and syndrome, following the holistic and dynamic principles. Departure from the holistic principle, separating the syndrome from the prescription, ignoring the dynamic concepts may possibly lose the features and advantages of syndrome typing and Chinese medicine preparations. The metabolomics research bridges the study of prescription and syndrome. It is of great significance in finding out the agreeable point of disease-syndrome-efficacy, establishing a dynamic research method with combination of disease and syndrome, correspondence of prescription and syndrome.