Methyl salicylate lactoside improves spatial memory and learning abilities of Alzheimer' s transgenic mice / 中国药理学通报

Aim To investigate the effect of methyl salicylate lactoside (MSL) on the spatial memory and learning of Alzheimer' s disease mice. Methods APP/PS1 double transgenic mice were used as AD animal model to evaluate behavioral changes by Morris water test. At the end of the experiment the brain tissues were fixed for assessment of A(3 deposition by immunohistochemistry, neuronal function changes by Nissl staining, neuronal morphological changes by transmission electron microscopy. Results The results showed that MSL could improve the spatial learning and memory abilitiesof AD mice by shortening latency time, prolonging time spent in target quadrant and increasing number of crossings of APP/PS1 mice. MSL could reduce partial Aβ deposition, alleviate the damage of nerve cells and improve the ultrastructural lesions of neuropil projections. Conclusion MSL could reduce Aβ deposition and protect neurons through anti-inflammatory effects, thus improving the learning and memory abilities of Alzheimer' s APP/PS1 transgenic mice.

Monitoring results on Mycobacterium tuberculosis drug resistance from 2010 to 2013 in Kaihua County of Zhejiang Province / 上海预防医学

Objective To analyze the multidrug resistant situation with Mycobacterium tuberculosis in Kaihua county in order to provide technical basis for formulating measures on tuberculosis control. Methods Mycobacterium tuberculosis were cultivated, which were collected from smear positive tuberculosis patients'sputum in People's Hospital of Kaihua County from January 2010 to December 2013. Proportion method for Mycobacterium tuberculosis drug sensitivity test was conducted to 6 anti-tuberculosis drugs (isoniazide, rifampin, ethambutol, streptomycin, levofloxacin, kanamycin). Results In 219 Mycobacterium tuberculosis culture positive patients, the rate of total drug resistance was 21.46% and the rate of total multidrug resistance 3 .20%;the rate of initial drug resistance was 19 .69%, and the rate of initial multidrug resistance 0.52%;the rate of acquired drug resistance was 34.62%, and the rate of acquired multidrug resistance 23.08%. Conclusion The rate of total drug resistance, total multidrug resistance, initial drug resistance, initial multidrug resistance and acquired drug resistance are respectively less than the result of The 5th National Tuberculosis Epidemiological Survey, while the rate of acquired multidrug resistance is more than the latter.