Design and organization of neuroscience oriented training mode for medical postgraduates / 医学研究生学报

In order to promote the development of medical and biological fields and help the students trained under the existing system to form a clear overall view on neuroscience research, the author summarizes a systematic chart teaching method in the teaching process of neuroscience which helps the students understand easily. On the basis of theory studying, the article induces and interprets the priorities and hotspots in domestic neuroscience research, which not only cultivates students' interest and enthusiasm in scientific research but also facilitates the training process. It tries to seek the improvement of the education quality from the teachers' perspective and contribution and effectively inspire students' spontaneous excavation in research direction which combines mentor's research field and their own interest, leading students to innovate good learning habits constantly.

Neuroprotective Effect of Ginsenoside Rg1 on Oxidative Damage Induced by Oxygen-glucose Deprivation and Reperfusion in Cultured Hippocampal Cells / 中国康复理论与实践

@#Objective To explore the effect of Ginsenoside Rgl on glutathion (GSH) level and glutathion peroxidase (GPx) activity after oxygen-glucose deprivation/reperfusion in cultured hippocampal cells. Methods The model of oxygen-glucose deprivation and reperfusion were established with the hippocampal neurons of rats. They were randomly divided into control group, model group and Ginsenoside Rgl treatment groups (5 μmol/L, 20 μmol/L, 60 μmol/L). The GSH level and GPx activity were measured 6 h after reperfusion. The apoptosis and the metabolic rate of methyl thiazolyl tetrazolium (MTT) were detected 24 h after reperfusion. Results Compared with model group, the GSH level, GPx activity, and metabolic rate of MTT improved (P<0.001), and the apoptosis decreased in the Ginsenoside Rgl groups (P<0.001) except with the dosage of 5 μmol/L (P>0.05). Conclusion Ginsenoside Rgl can protect the brain from ischemia by increasing the GSH level and GPx activity.

Efficacy of laparoscopic gastric bypass on simple obesity patients and analysis of influence factors / 中华胃肠外科杂志

<p><b>OBJECTIVE</b>To evaluate the outcomes and factors related to weight loss after laparoscopic gastric bypass(LGBP) in obese patients.</p><p><b>METHODS</b>Forty-one obese patients who underwent LGBP from May 2010 to December 2011 in the First Affiliated Hospital of Nanjing Medical University were followed up. The operative time, intraoperative complications, postoperative complications, preoperative body mass index(BMI), postoperative BMI, and excess weight loss rate(EWL) were determined and their correlation with efficacy were analyzed.</p><p><b>RESULTS</b>All the surgeries were successful without conversions or perioperative deaths. The average operative time was (229±96)min, intraoperative blood loss was(15±3) ml, postoperative hospital stay was(5.7±1.7) d. Patients were followed up for 3-12 months. The average EWL at 1, 3, 6, 9, and 12 months after operation was 24.2%, 45.6%, 60.1%, 66.5% and 69.0%. The EWL was negatively correlated with preoperative BMI(P<0.01), but not correlated with age, gender, and waist-hip ratio(all P>0.05). Postoperative short-term EWL did not differ between central obesity patients and peripheral obesity patients, and before and after standardized treatment(both P>0.05). After standardization, however, operative time and postoperative hospital stay were significantly reduced(P<0.01).</p><p><b>CONCLUSIONS</b>LGBP is an effective and feasible treatment for obesity patients. Short-term efficacy after surgery is negatively correlated with preoperative BMI. Standardization may reduce operative time and postoperative hospital stay, but not associated with improved short-term outcomes.</p>

From the bariatric surgery history to select operation procedure / 中华胃肠外科杂志

Bariatric surgery has developed in western countries for more than 50 years. With the increase of obese patients in China, the surgical treatment of obesity anf diabetes become acceptable. it is important to review the history of bariatric surgery and summarize suitable procedures for Chinese bariatric surgery including Roux-en-Y gastric bypass, sleeve gastrectomy, and adjustable gastric band. Appropriate procedure selection is made according to the condition of patients and their desire. It is very important to follow up all the patients postoperatively, and achieve the best bariatric outcomes.

Comparison of different mechanisms in the treatment of type 2 diabetes between biliopancreatic diversion and Roux-en-Y gastric bypass / 中华胃肠外科杂志

A large number of clinical studies indicate that bariatric surgery leads to improvement or resolution of type 2 diabetes. The outcomes vary depending on procedure adopted. Biliopancreatic diversion(BPD) is associated with the highest cure rate(98%), followed by Roux-en-Y gastric bypass(RGBP)(80%). However, the mechanism is still unclear and controversial. The changes of many hormones after surgery are different between BPD and RGBP, especially some gastrointestinal hormones such as GLP-1 and GIP,however it cannot be fully explained by the widely known hindgut hypothesis and the foregut hypothesis. This review is intended to compare the anatomical structures and postoperative gastrointestinal hormones GLP-1 and GIP changes between the two procedures according to the latest researches in the world, and discussed different mechanisms which may take effect in improving diabetes.