Chemical constituents and pharmacological effects of Phytolaccae Radix and prediction of quality markers: research advances / 国际药学研究杂志

Phytolaccae Radix is a traditional Chinese herbal medicine. In recent years, its study has gradually been deepened, and its effective ingredients and pharmacological effects have attracted much attention, and it has broad application prospects in the treatment of various diseases. Phytolaccae Radix mainly contains triterpenoid saponins, polysaccharides, flavonoids, phenolic acids and other components. According to modern pharmacological studies, it has diuretic, immunomodulatory and expectorant effects. On the basis of the studies, and according to the definition of quality marker(Q-marker), we predict its Q-markers from the aspects of the traditional efficacy, traditional medicinal properties, new clinical use, measurable composition, composition changes before and after processing, the plasma composition, and so on, which provides a scientific basis for the quality evaluation of Phytolaccae Radix.

Modified urethral pull-through procedure for posterior urethral stricture or atresia / 中华男科学杂志

<p><b>OBJECTIVE</b>To evaluate the feasibility and safety of the modified urethral pull-through procedure for the treatment of posterior urethral stricture or atresia.</p><p><b>METHODS</b>We retrospectively analyzed 212 cases of posterior urethral stricture or atresia treated by the modified urethral pull-through procedure. The length of the stricture or atresia was 1.5 - 12 cm, and 66 cases had experienced 1 - 4 previous unsuccessful urethral repairs. Simple transperineal approach was adopted in 208 cases and transperineal-inferiorpubic approach in the other 4. And 15 of the patients underwent urethral construction with grafts.</p><p><b>RESULTS</b>Satisfactory voiding was achieved in 198 (93.4%) of the patients, of whom 16 received 3 - 15 urethral dilations. Of the 14 cases that failed, 10 succeeded after a second and 2 after a third operation. Of the 15 cases that underwent substitution urethroplasty, 14 achieved satisfactory voiding, and only 1 needed repeat dilation. No serious complications were observed in any of the patients.</p><p><b>CONCLUSION</b>Modified urethral pull-through procedure, with its advantages of safety, mini-invasiveness, simple operation and high success rate, is feasible for the treatment of posterior urethral stricture or atresia, while for that with the length >5 cm, substitution urethroplasty should be considered.</p>