ABSTRACT
@#Objective To analyze the association between serum homocysteine (Hcy),white matter hyperintensity (WMH) and cerebral microbleeds (CMBs).Methods 309 patients were divided into CMBs group (n=116) and control group (n=193),lobar CMBs group (n=90) and deep CMBs group (n=26),minor CMBs group (n=78) and major CMBs group (n=38),low-level Hcy group (n=158) and high level Hcy group (n=151) according to the quantity and site of CMBs and the median levels of Hcy.Results The levels of Hcy,glucose,creatinine,the total score of Fazekas scale,systolic pressure and pulse pressure difference were higher in CMBs group than control group (P<0.05);Male,systolic pressure and the total score of Fazekas scale were independent risk factors of CMBs by Logical regression (P<0.05).The scores of Fazekas scale were higher in lobar CMBs group than deep CMBs group (P<0.05);Serum Hcy,the scores of Fazekas scale were related to quantity of CMBs (P<0.05).Conclusions The serum Hcy was partcipated in the process of CMBS.The severity of WMH was correlation with lobar CMBs may play a prediction role in CMBs.
ABSTRACT
Objective To analyze the clinical and laboratory characteristics of the ischemic stroke in patients with non-valvular atrial fibrillation (AF), and to provide evidence for the prevention of ischemic stroke. Methods A total of 198 patients with ischemic stroke were chosen and divided into two groups:with AF (71 patients)/and without AF (127 patients) groups. Clinical data and biochemical markers were collected and compared in two groups. CHADS2 and CHA2DS2-VASc score systems were used to determine the risk levels in patients with AF. Finally, related risk factors of ischemic stroke with AF were determined and analyzed. Results The values of age, length of hospital stay, the hypertention history, heart rate and plasma homocysteine (Hcy) were significantly higher in the with-AF group than those in the without-AF group ( P <0.05). The levels of total cholesterol (TC), triglyceride (TG) and very low density lipoprotein cholesterol (VLDL-C) were sig?nificantly lower in the with-AF group than those of the without-AF group (P<0.05). CHA2DS2-VASc scores reached to the moderate-to-high risk level in the with-AF group. Multiple-factor logistic regression analysis showed that age and heart rate were the independent risk factors of the ischemic stroke in patients with non-valvular AF. ROC analysis indicated that age (AUC=0.761, cut-off point=72.50 years old) and heart rate (AUC=0.612, cut-off point=76.50 bit/min) had predictive and di?agnostic value for the ischemic stroke in patients with non-valvular AF. The age of these patients had the best sensitivity (70.4%) and specifity (71.1%), and the cut-off point of which was 72.50 years old. Conclusion The characteristics of isch?emic stroke in patients with non-valvular AF includes older age, faster heart rate, higher CHA2DS2-VASc scores and higher Hcy level.
ABSTRACT
ObjectiveTo study the relation ship between progressive cerebral infarction and thyroid hormone level,and analyze the risk factors of progressive cerebral infarction.MethodsThe thyroid hormone,triglyceride esters and fasting glucose levels of 48 patients with progressive cerebral infarction,138 patients with non-progressive cerebral infarction and 60 healthy subjects as control group were measured.ResultsCompared with the patients with non-progressive cerebral infarction,serum T3 of patients with progressive cerebral infarction was lower( P ＜0.05),and the levels of triglyceride ( TG),C-reactive protein ( CRP),and fasting blood glucose were higher ( all P ＜ 0.01 ).ConclusionPatients with progressive cerebral infarction were in a low level of thyroid hormones,and the increasing levels of TG,CRP,and fasting blood glucose were risk factors for progressive cerebral infarction.
ABSTRACT
This article summarizes the components,the formation and development of carotid atherosclerotic plaque,the factors affecting the stability of plaque,the mechanisms of plaquecaused ischemic cerebrovascular disease as well as the diagnosis of plaques and the treatmentstatus.