ABSTRACT
Acute hypobaric hypoxic brain damage is a potentially fatal high-altitude sickness. Autophagy plays a critical role in ischemic brain injury, but its role in hypobaric hypoxia (HH) remains unknown. Here we used an HH chamber to demonstrate that acute HH exposure impairs autophagic activity in both the early and late stages of the mouse brain, and is partially responsible for HH-induced oxidative stress, neuronal loss, and brain damage. The autophagic agonist rapamycin only promotes the initiation of autophagy. By proteome analysis, a screen showed that protein dynamin2 (DNM2) potentially regulates autophagic flux. Overexpression of DNM2 significantly increased the formation of autolysosomes, thus maintaining autophagic flux in combination with rapamycin. Furthermore, the enhancement of autophagic activity attenuated oxidative stress and neurological deficits after HH exposure. These results contribute to evidence supporting the conclusion that DNM2-mediated autophagic flux represents a new therapeutic target in HH-induced brain damage.
Subject(s)
Mice , Animals , Hypoxia , Oxidative Stress , Autophagy , Cognition , Sirolimus/therapeutic useABSTRACT
Objective To construct a"Field and Disaster Nursing"course which is suitable for the military and local higher nursing education, on-the-job and post training education to organic integrate the modern disaster nursing teaching and military field nursing teaching. Methods Based on the methods of qualitative and quantitative research, such as literature research, interviews and observational method, a preliminary plan of curriculum design was established, and an expert consultation table was designed.The Delphi expert consultation method was used to conduct two rounds of consultation with 30 related experts on disaster relief.Quantitative data were obtained and statistical data were analyzed. Results The final screening results of the curriculum content applicability index are 4 first grade, and 23 for the two level.A set of"Field and Disaster Nursing"curriculum had been set up that is suitable for education and training needs of the military and local fusion. Conclusion The construction of this course provides a training thought for exploring disaster nursing education suitable for China's national conditions, and has reference and guiding significance for further implementation of military and civilian integration and multi participatory disaster nursing teaching practice.
ABSTRACT
The National Standards for the Quality of Nursing Teaching is the core outline for deepening the teaching reform of undergraduate nursing majors in higher education and improving the quality of nursing professionals. Since its establishment, Lanzhou University School of Nursing has been confronted with educational difficulties, overcome difficulties and promote professional development, continued to develop in the western region, and conducted research and study in a characteristic way. Our school conscientiously and strictly follow the standard, constantly clarify the objectives of the school, improve managerial condition, enhance the level of professional connotation construction, formed a "core competencies" oriented training mode, continued the development of "high standard, with characteristic" the road. Our school unifies the standard to make up the gap insufficient, and prepare for greeting the nursing profession certification work carefully.
ABSTRACT
The National Standards for the Quality of Nursing Teaching is the core outline for deepening the teaching reform of undergraduate nursing majors in higher education and improving the quality of nursing professionals. Since its establishment, Lanzhou University School of Nursing has been confronted with educational difficulties, overcome difficulties and promote professional development, continued to develop in the western region, and conducted research and study in a characteristic way. Our school conscientiously and strictly follow the standard, constantly clarify the objectives of the school, improve managerial condition, enhance the level of professional connotation construction, formed a "core competencies" oriented training mode, continued the development of "high standard, with characteristic"the road. Our school unifies the standard to make up the gap insufficient, and prepare for greeting the nursing profession certification work carefully.
ABSTRACT
Objective To discuss the community-based psychological support model for people living with HIV/AIDS. Methods A community-based psychological support team was set up. The team composed of psychology experts,community volunteers,community physicians,community nurses and family members of patients. It provided psychological care and emotional support to people living with HIV/AIDS through activities such as psychological counseling,health education,anti-discrimination advocacy and peer exchanges. Results This model significantly reduced the anxiety and depression,and increased life satisfaction of people living with HIV/AIDS(P<0.01). Conclusions The community-based psychological support model has more advantages than the traditional psychological support. It gives full play to the community on AIDS prevention and control functions,as well as has great significance to mobilize social forces to control the spread of AIDS.
ABSTRACT
Objective To study the relationship between the biologic behaviours of gastric carcinoma (GC) and the immune reaction cells of GC tissue. Methods One hundred and seven radical gastrectomy specimens and 3 to 8 years follow-up data were quantitatively assessed on the reactive degree of lymph-plasma cells and eosinophils with CMIAS image analysis system. Mast cell reaction was accounted in the low power microscopy. Each indicator was divided into two groups, high reaction group and low reaction group, according to the intensity of reactions. Both high reaction and low reaction group were analysed on the base of clinicopathologic parameters. Results There was a significant difference in the survival time, depth of tumour invasion and lymph node metastasis in GC tissue between high reaction group and low reaction group (P<0.05). Conclusions Local immune reaction cells plays an important role in the defense mechanism of GC host against the tumour cells invising and spreading.