ABSTRACT
We reviewed 100 cases with Guillain-Barré syndrome (GBS) from 1980 to 1999, and found that the features of GBS in electrophysiological classification, age, area, seasonal distributions, and in preceding illness in northwestern China are different in some aspects from those in Europe and North America or in northern China. The demyelinating pattern appeares as a major subtype not only in different age groups, but also in different test times after symptom onset.
ABSTRACT
Objective To compare the curative effects and safety of immunoabsorption(IA) and double filtration plasmapheresis(DFPP) in treatment of Guillain-Barre syndrome(GBS).Methods 60 patients of GBS were randomly divided into two groups and treated with IA and DFPP,respectively.The neurological functions were assessed and the immunoglobulin,complement and total protein in the blood were also measured before and after treatments.Results The rating of the neurological function deficiency in both groups improved with time,but there was no significant difference in Hughes rating between two groups.After half year,the MRC rating in IA group was better than that in DFPP group((P
ABSTRACT
AIM To examine the effect of metabotropic glutamate receptor ligand (s) 4 carboxy 3 hydroxyphenyl glycine 〔(s) 4C3HPG〕 on kainic acid induced epileptic seizures and brain damage in rats. METHODS Rats were given (s) 4C3HPG (500 nmol/rat) by icv infusion prior to kainic acid (KA) injection ip(10 mg?kg -1 ). The behavoir changes, electrographic seizure duration and histological alterations between different group of rats were compared. RESULTS (s) 4C3HPG markedly reduced seizures severity in response to kainate. The seizure score in the rat with (s) 4C3HPG injection icv was significantly lower than that of control during the first three hours observation period after KA administration ( P